دورية أكاديمية
Prevalence and correlates of elevated serum creatinine levels: the Framingham Heart Study.
| العنوان: | Prevalence and correlates of elevated serum creatinine levels: the Framingham Heart Study. |
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| المؤلفون: | Culleton BF; National Heart, Lung, and Blood Institute's Framingham Heart Study, MA 01702, USA., Larson MG, Evans JC, Wilson PW, Barrett BJ, Parfrey PS, Levy D |
| المصدر: | Archives of internal medicine [Arch Intern Med] 1999 Aug 9-23; Vol. 159 (15), pp. 1785-90. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Medical Assn Country of Publication: United States NLM ID: 0372440 Publication Model: Print Cited Medium: Print ISSN: 0003-9926 (Print) Linking ISSN: 00039926 NLM ISO Abbreviation: Arch Intern Med Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Chicago, American Medical Assn. |
| مواضيع طبية MeSH: | Creatinine/*blood , Kidney Failure, Chronic/*blood, Adult ; Age Factors ; Aged ; Cardiovascular Diseases/blood ; Cross-Sectional Studies ; Diabetes Mellitus/blood ; Disease Progression ; Female ; Humans ; Logistic Models ; Male ; Massachusetts/epidemiology ; Middle Aged ; Odds Ratio ; Predictive Value of Tests ; Prevalence ; Risk Factors |
| مستخلص: | Background: Elevated serum creatinine (SCr) levels are a predictor of end-stage renal disease, but little is known about the prevalence of elevated SCr levels and their correlates in the community. Methods: In this cross-sectional, community-based sample, SCr levels were measured in 6233 adults (mean age, 54 years; 54% women) who composed the "broad sample" of this investigation. A subset, consisting of 3241 individuals who were free of known renal disease, cardiovascular disease, hypertension, and diabetes, constituted the healthy reference sample. In this latter sample, sex-specific 95th percentiles for SCr levels (men, 136 micromol/L [1.5 mg/dL]; women, 120 micromol/L [1.4 mg/dL]) were labeled cutpoints. These cutpoints were applied to the broad sample in a logistic regression model to identify prevalence and correlates of elevated SCr levels. Results: The prevalence of elevated SCr levels was 8.9% in men and 8.0% in women. Logistic regression in men identified age, treatment for hypertension (odds ratio [OR], 1.75; 95% confidence interval [CI], 1.27-2.42), and body mass index (OR, 1.08; 95% CI, 1.01-1.15) as correlates of elevated SCr levels. Additionally, men with diabetes who were receiving antihypertensive medication were more likely to have raised SCr values (OR, 2.94; 95% CI, 1.60-5.39). In women, age, use of cardiac medications (OR, 1.58; 95% CI, 1.10-2.96), and treatment for hypertension (OR, 1.42; 95% CI, 1.07-1.87) were associated with elevated SCr levels. Conclusions: Elevated SCr levels are common in the community and are strongly associated with older age, treatment for hypertension, and diabetes. Longitudinal studies are warranted to determine the clinical outcomes of individuals with elevated levels of SCr and to examine factors related to the progression of renal disease in the community. |
| معلومات مُعتمدة: | N01-HC-38038 United States HC NHLBI NIH HHS |
| المشرفين على المادة: | AYI8EX34EU (Creatinine) |
| تواريخ الأحداث: | Date Created: 19990817 Date Completed: 19990826 Latest Revision: 20190812 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1001/archinte.159.15.1785 |
| PMID: | 10448783 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0003-9926 |
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| DOI: | 10.1001/archinte.159.15.1785 |