دورية أكاديمية
Catalase gene is associated with facial eczema disease resistance in sheep.
| العنوان: | Catalase gene is associated with facial eczema disease resistance in sheep. |
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| المؤلفون: | Phua SH; Department of Biochemistry, University of Otago, Dunedin, New Zealand., Dodds KG, Morris CA, Paterson KA, McEwan JC, Garmonsway HG, Towers NR, Crawford AM |
| المصدر: | Animal genetics [Anim Genet] 1999 Aug; Vol. 30 (4), pp. 286-95. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 8605704 Publication Model: Print Cited Medium: Print ISSN: 0268-9146 (Print) Linking ISSN: 02689146 NLM ISO Abbreviation: Anim Genet Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Oxford, England : Wiley-Blackwell Original Publication: Oxford, England : Published by Blackwell Scientific Publications for the International Society for Animal Blood Group Research, c1986- |
| مواضيع طبية MeSH: | Catalase/*genetics , Eczema/*veterinary , Sheep/*genetics , Sheep/*metabolism , Sheep Diseases/*enzymology , Sheep Diseases/*genetics, Alleles ; Animals ; Base Sequence ; Chromosomes, Artificial, Yeast/genetics ; Crosses, Genetic ; DNA Primers/genetics ; Eczema/enzymology ; Eczema/genetics ; Face ; Female ; Gene Frequency ; Male ; Microsatellite Repeats ; Mycoses/enzymology ; Mycoses/genetics ; Mycoses/veterinary ; Physical Chromosome Mapping ; Sporidesmins/toxicity |
| مستخلص: | Facial eczema (FE) is a hepatogenous photosensitization disease of ruminant animals, particularly in sheep which vary widely in their susceptibility to the disease. The liver damage is caused by the mycotoxin, sporidesmin. There is evidence that the toxicity of sporidesmin is due to its ability to generate 'active oxygen' species. We evaluated the catalase gene, which encodes an enzyme with antioxidant functions, as a candidate for determining the susceptibility of sheep to the disease. Two microsatellite markers, OarSHP3 and OarSHP4, which flank the sheep catalase gene, were isolated from a Yeast Artificial Chromosome (YAC) clone. These markers mapped the catalase locus by linkage to ovine chromosome 15. Eleven informative markers spaced throughout chromosome 15, inclusive of the catalase marker OarSHP4, gave no significant linkage with the disease traits when analysed in four outcross resource pedigrees. However, OarSHP3 and OarSHP4 allele frequencies showed significant differences between FE resistant and susceptible selection-lines. Comparison of sequences of catalase cDNAs from sheep of resistant and susceptible lines showed only two silent mutations. A single nucleotide polymorphisms (KP1) in exon 6 of the catalase gene also showed significant differences in allele frequencies between the selection lines. The lack of evidence for linkage in outcross pedigrees, but the significant association in the genetic lines, implies that catalase is involved in determining the susceptibility of sheep to facial eczema, and that the candidate gene's effect is probably recessive or minor. |
| المشرفين على المادة: | 0 (DNA Primers) 0 (Sporidesmins) EC 1.11.1.6 (Catalase) |
| تواريخ الأحداث: | Date Created: 19990901 Date Completed: 19991004 Latest Revision: 20190915 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1046/j.1365-2052.1999.00516.x |
| PMID: | 10467703 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0268-9146 |
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| DOI: | 10.1046/j.1365-2052.1999.00516.x |