دورية أكاديمية
Severe injury triggers antigen-specific T-helper cell dysfunction.
| العنوان: | Severe injury triggers antigen-specific T-helper cell dysfunction. |
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| المؤلفون: | Kelly JL; Department of Surgery (Immunology), Harvard Medical School/Brigham and Women's Hospital, Boston, MA 02115, USA., O'Suilleabhain CB, Soberg CC, Mannick JA, Lederer JA |
| المصدر: | Shock (Augusta, Ga.) [Shock] 1999 Jul; Vol. 12 (1), pp. 39-45. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 9421564 Publication Model: Print Cited Medium: Print ISSN: 1073-2322 (Print) Linking ISSN: 10732322 NLM ISO Abbreviation: Shock Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2002- : Philadelphia : Lippincott Williams & Wilkins Original Publication: Augusta, GA : BioMedical Press, [1994- |
| مواضيع طبية MeSH: | Immunity*, Burns/*immunology , Th1 Cells/*immunology , Th2 Cells/*immunology, Animals ; Antibody Formation ; Antigen Presentation ; Immunization ; Interferon-gamma/biosynthesis ; Interferon-gamma/immunology ; Interleukin-10/biosynthesis ; Interleukin-10/immunology ; Interleukin-2/biosynthesis ; Interleukin-2/immunology ; Male ; Mice |
| مستخلص: | Although it is established that post-injury immune dysfunction involves alterations in T-cell function, the effects of injury on T-cell function in vivo are poorly understood. This study uses a mouse injury model and an antigen immunization approach to investigate the influence of injury on antigen-specific T-helper cell function. We report here that injury triggered a significant reduction in antigen-specific T-helper-1 (Th1)-dependent IgG2a antibody formation, while IgM, IgG1, and IgE production was unchanged. In addition, injury caused a reduction in cytokine production (IL-2, IFNgamma and IL-10) by antigen-stimulated T-cells. We also demonstrate that interleukin 12 (IL-12), a cytokine that promotes Th1 cell differentiation, restored IgG2a antibody formation and corrected the injury-induced reduction in antigen-stimulated cytokine production. Taken together, these findings indicate that severe injury induces a dramatic reduction in Th1 cell function in vivo and suggest that therapies designed to restore Th1 cell function may be beneficial to the injured host. |
| معلومات مُعتمدة: | GM 35633 United States GM NIGMS NIH HHS |
| المشرفين على المادة: | 0 (Interleukin-2) 130068-27-8 (Interleukin-10) 82115-62-6 (Interferon-gamma) |
| تواريخ الأحداث: | Date Created: 19990901 Date Completed: 19990921 Latest Revision: 20190915 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1097/00024382-199907000-00006 |
| PMID: | 10468050 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1073-2322 |
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| DOI: | 10.1097/00024382-199907000-00006 |