دورية أكاديمية
"Spontaneously" hypertensive mice: a potential genetic model for the study of the relationship between heart size and blood pressure.
| العنوان: | "Spontaneously" hypertensive mice: a potential genetic model for the study of the relationship between heart size and blood pressure. |
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| المؤلفون: | Elias MF, Sorrentino RN, Pentz CA 3rd, Florini JR |
| المصدر: | Experimental aging research [Exp Aging Res] 1975 Nov; Vol. 1 (2), pp. 251-65. |
| نوع المنشور: | Journal Article; Research Support, U.S. Gov't, P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: Routledge Country of Publication: United States NLM ID: 7603335 Publication Model: Print Cited Medium: Print ISSN: 0361-073X (Print) Linking ISSN: 0361073X NLM ISO Abbreviation: Exp Aging Res Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2005->: New York : Routledge Original Publication: Bar Harbor, Me., EAR, inc. |
| مواضيع طبية MeSH: | Blood Pressure*, Heart/*anatomy & histology , Hypertension/*physiopathology, Age Factors ; Analysis of Variance ; Animals ; Body Weight ; Female ; Hypertension/genetics ; Male ; Mice ; Models, Genetic ; Myocardium/metabolism ; Organ Size ; Protein Biosynthesis |
| مستخلص: | Mice selected genetically for high and low blood pressure (BP) were compared with regard to heart weight and heart/body ratios. Two experiments were performed with mice ranging in age from 1.3 to 9 months and 11 to 23 months respectively. In a third experiment C57BL/6J mice were compared to the high and low BP mice. Heart/body ratios and heart weights, adjusted fo body weight via covariance analysis, were significantly greater for the high BP mice, but no Age x BP Genotype interaction was observed. Results were discussed in terms of a possible relationship between heart weight and BP via genetic linkage or pleiotropy. The possibility was also raised that compensatory mechanisms for high blood pressure, e.g., cardiac hypertrophy, may operate very early in development for animals who are hypertensive by virtue of selective breeding for blood pressure extremes. |
| معلومات مُعتمدة: | AG 00473 United States AG NIA NIH HHS; HL 1151 United States HL NHLBI NIH HHS |
| تواريخ الأحداث: | Date Created: 19751101 Date Completed: 19810513 Latest Revision: 20080225 |
| رمز التحديث: | 20240829 |
| DOI: | 10.1080/03610737508257964 |
| PMID: | 1053214 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 0361-073X |
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| DOI: | 10.1080/03610737508257964 |