دورية أكاديمية
أعرض في EDS

c-Myc enhances protein synthesis and cell size during B lymphocyte development.

التفاصيل البيبلوغرافية
العنوان: c-Myc enhances protein synthesis and cell size during B lymphocyte development.
المؤلفون: Iritani BM; Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109-1024, USA., Eisenman RN
المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 1999 Nov 09; Vol. 96 (23), pp. 13180-5.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
اللغة: English
بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print Cited Medium: Print ISSN: 0027-8424 (Print) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Washington, DC : National Academy of Sciences
مواضيع طبية MeSH: B-Lymphocytes/*cytology , Cell Size/*physiology , Proto-Oncogene Proteins c-myc/*physiology, Animals ; Cell Cycle ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Proto-Oncogene Proteins c-myc/biosynthesis ; Transgenes
مستخلص: Members of the myc family of nuclear protooncogenes play roles in cell proliferation, differentiation, and apoptosis. Moreover, inappropriate expression of c-myc genes contributes to the development of many types of cancers, including B cell lymphomas in humans. Although Myc proteins have been shown to function as transcription factors, their immediate effects on the cell have not been well defined. Here we have utilized a murine model of lymphomagenesis (Emu-myc mice) to show that constitutive expression of a c-myc transgene under control of the Ig heavy-chain enhancer (Emu) results in an increase in cell size of normal pretransformed B lymphocytes at all stages of B cell development. Furthermore, we show that c-Myc-induced growth occurs independently of cell cycle phase and correlates with an increase in protein synthesis. These results suggest that Myc may normally function by coordinating expression of growth-related genes in response to mitogenic signals. Deregulated c-myc expression may predispose to cancer by enhancing cell growth to levels required for unrestrained cell division.
References: Mol Cell Biol. 1984 Nov;4(11):2486-97. (PMID: 6513926)
Genes Dev. 1989 Jun;3(6):860-9. (PMID: 2663644)
Genes Dev. 1993 Apr;7(4):671-82. (PMID: 8458579)
Mol Gen Genet. 1976 Jul 23;146(2):167-78. (PMID: 958201)
Curr Opin Cell Biol. 1998 Dec;10(6):784-90. (PMID: 9914170)
Cell Growth Differ. 1997 Oct;8(10):1039-48. (PMID: 9342182)
Proc Natl Acad Sci U S A. 1996 May 14;93(10):4683-7. (PMID: 8643464)
EMBO J. 1991 Jan;10(1):133-41. (PMID: 1989881)
Nature. 1992 Oct 1;359(6394):423-6. (PMID: 1406955)
Cell. 1999 Sep 17;98(6):779-90. (PMID: 10499795)
Annu Rev Immunol. 1988;6:25-48. (PMID: 2838049)
Nature. 1991 Sep 26;353(6342):361-3. (PMID: 1833648)
Curr Top Microbiol Immunol. 1997;224:19-30. (PMID: 9308225)
Oncogene. 1992 May;7(5):981-6. (PMID: 1570158)
Nature. 1985 Mar 28-Apr 3;314(6009):366-9. (PMID: 3885045)
J Immunol. 1987 Dec 1;139(11):3854-60. (PMID: 2445821)
Oncogene Res. 1988;3(3):271-9. (PMID: 3144697)
Biotechniques. 1998 Sep;25(3):522-5. (PMID: 9762450)
Trends Biochem Sci. 1997 May;22(5):177-81. (PMID: 9175477)
Cell Growth Differ. 1993 May;4(5):349-57. (PMID: 8518229)
Adv Cancer Res. 1991;56:1-48. (PMID: 2028839)
Nature. 1985 Dec 12-18;318(6046):533-8. (PMID: 3906410)
Exp Cell Res. 1977 Mar 1;105(1):79-98. (PMID: 320023)
Genes Dev. 1992 Jan;6(1):71-80. (PMID: 1730411)
Mol Cell. 1999 Feb;3(2):169-79. (PMID: 10078200)
Cell. 1983 Dec;35(3 Pt 2):603-10. (PMID: 6606489)
J Mol Biol. 1971 Jul 14;59(1):183-94. (PMID: 5283752)
J Exp Med. 1988 Feb 1;167(2):353-71. (PMID: 3258007)
EMBO J. 1983;2(12):2385-9. (PMID: 6321165)
Nature. 1984 Oct 4-10;311(5985):433-8. (PMID: 6090941)
Nature. 1992 Oct 1;359(6394):426-9. (PMID: 1406956)
Cell. 1986 Oct 10;47(1):11-8. (PMID: 3093082)
Cell. 1984 Feb;36(2):241-7. (PMID: 6692471)
EMBO J. 1994 Sep 1;13(17):4070-9. (PMID: 8076602)
Cell. 1991 May 31;65(5):753-63. (PMID: 1904009)
EMBO J. 1990 Mar;9(3):897-905. (PMID: 2155783)
Science. 1999 Jan 29;283(5402):676-9. (PMID: 9924025)
Oncogene. 1989 Jun;4(6):773-87. (PMID: 2660073)
Cell. 1989 Feb 24;56(4):673-82. (PMID: 2537153)
Adv Cancer Res. 1986;47:189-234. (PMID: 3096089)
Mol Cell Biol. 1999 Jan;19(1):1-11. (PMID: 9858526)
Adv Cancer Res. 1996;68:109-82. (PMID: 8712067)
J Exp Med. 1991 May 1;173(5):1213-25. (PMID: 1827140)
Curr Opin Genet Dev. 1999 Feb;9(1):76-80. (PMID: 10072360)
Oncogene. 1991 May;6(5):797-805. (PMID: 2052358)
Cell. 1991 May 3;65(3):395-407. (PMID: 1840505)
Cell. 1991 May 31;65(5):737-52. (PMID: 1904008)
Genes Dev. 1992 Dec;6(12A):2235-47. (PMID: 1459449)
Oncogene. 1991 Oct;6(10):1915-22. (PMID: 1923514)
Cell. 1997 May 2;89(3):349-56. (PMID: 9150134)
Exp Cell Res. 1965 May;38:272-84. (PMID: 14284508)
EMBO J. 1997 Dec 1;16(23):7019-31. (PMID: 9384581)
Adv Cancer Res. 1990;55:133-270. (PMID: 2166998)
Science. 1991 Mar 8;251(4998):1211-7. (PMID: 2006410)
Neuron. 1993 Jan;10(1):1-9. (PMID: 8427698)
Mol Cell Biol. 1986 Mar;6(3):870-7. (PMID: 3022135)
EMBO J. 1999 Feb 1;18(3):717-26. (PMID: 9927431)
Immunity. 1999 Jun;10(6):713-22. (PMID: 10403646)
EMBO J. 1994 May 1;13(9):2124-30. (PMID: 8187765)
Oncogene. 1998 Aug 13;17(6):769-80. (PMID: 9715279)
معلومات مُعتمدة: K08 AI001445-06 United States AI NIAID NIH HHS; R01CA20525 United States CA NCI NIH HHS; 1 K08 AJ01445-01 United States PHS HHS; K08 AI001445-04 United States AI NIAID NIH HHS; R01 CA020525 United States CA NCI NIH HHS; HL54881 United States HL NHLBI NIH HHS; K08 AI001445-05 United States AI NIAID NIH HHS; P50 HL054881 United States HL NHLBI NIH HHS
المشرفين على المادة: 0 (Proto-Oncogene Proteins c-myc)
تواريخ الأحداث: Date Created: 19991111 Date Completed: 19991213 Latest Revision: 20230331
رمز التحديث: 20230331
مُعرف محوري في PubMed: PMC23921
DOI: 10.1073/pnas.96.23.13180
PMID: 10557294
قاعدة البيانات: MEDLINE
الوصف
تدمد:0027-8424
DOI:10.1073/pnas.96.23.13180