دورية أكاديمية
Fetal antigen hypothesis and ovarian cancer: is there an immunogenic explanation for the reduction in risk associated with parity?
| العنوان: | Fetal antigen hypothesis and ovarian cancer: is there an immunogenic explanation for the reduction in risk associated with parity? |
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| المؤلفون: | Mockett EJ; School of Public Health, University of Washington, and Cancer Prevention Program, Seattle, USA., Rossing MA, Weiss NS |
| المصدر: | Epidemiology (Cambridge, Mass.) [Epidemiology] 2000 Jan; Vol. 11 (1), pp. 55-8. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 9009644 Publication Model: Print Cited Medium: Print ISSN: 1044-3983 (Print) Linking ISSN: 10443983 NLM ISO Abbreviation: Epidemiology Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2000>- : Hagerstown, MD : Lippincott Williams & Wilkins Original Publication: [Cambridge, MA : Blackwell Scientific Publications ; Chestnut Hill, MA : Epidemiology Resources, c1990- |
| مواضيع طبية MeSH: | Fetal Blood/*immunology , Isoantigens/*immunology , Ovarian Neoplasms/*immunology , Parity/*immunology, Adult ; Aged ; Female ; Gravidity/immunology ; Humans ; Incidence ; Middle Aged ; Odds Ratio ; Ovarian Neoplasms/epidemiology ; Ovarian Neoplasms/etiology ; Pregnancy ; Pregnancy Outcome ; Retrospective Studies ; Risk Factors ; Sexual Behavior ; Washington/epidemiology |
| مستخلص: | The hypothesis that a woman's immunologic response to fetal antigens arising from paternal genes may explain some of the reduction in risk of ovarian cancer associated with parity has not, to our knowledge, been examined. We analyzed data from a case-control study to evaluate the risk of epithelial ovarian cancer among women of similar parity associated with proposed indices of paternally derived fetal antigen exposure. Cases included white women 20-79 years of age diagnosed with epithelial ovarian cancer in three counties in Washington State between January 1, 1986, and December 31, 1988 (N = 322). Controls (N = 426) were selected by random-digit dialing and were broadly similar to cases in age and county of residence. After excluding women who had fewer than two pregnancies (or, in some analyses, fewer than two livebirths) and adjusting for age and number of livebirths, we observed no reduction in risk associated with number of marriages or number of partners with whom a study participant conceived a pregnancy and/or had a child. Nevertheless, these relatively crude indices of exposure to paternally derived fetal antigens do not preclude the possibility that a woman's response to other fetal or pregnancy-related antigens may antagonize the development of ovarian cancer. |
| المشرفين على المادة: | 0 (Isoantigens) |
| تواريخ الأحداث: | Date Created: 20000101 Date Completed: 20000119 Latest Revision: 20190915 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1097/00001648-200001000-00012 |
| PMID: | 10615844 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1044-3983 |
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| DOI: | 10.1097/00001648-200001000-00012 |