دورية أكاديمية

[Chronic rejection of renal allografts. Part 1. Present knowledge of etiopathogenesis].

التفاصيل البيبلوغرافية
العنوان: [Chronic rejection of renal allografts. Part 1. Present knowledge of etiopathogenesis].
عنوان ترانسليتريتد: Chronická rejekce renálního alostĕpu. Cást 1. Soucasné poznatky o etiopatogenezi.
المؤلفون: Viklický O; Klinika nefrologie, Transplantcentrum, IKEM, Praha., Matl I, Heemann UW
المصدر: Casopis lekaru ceskych [Cas Lek Cesk] 1999 Nov 29; Vol. 138 (23), pp. 711-5.
نوع المنشور: English Abstract; Journal Article; Review
اللغة: Czech
بيانات الدورية: Publisher: Ceskoslovenska Lekarska Spolecnost Country of Publication: Czech Republic NLM ID: 0004743 Publication Model: Print Cited Medium: Print ISSN: 0008-7335 (Print) Linking ISSN: 00087335 NLM ISO Abbreviation: Cas Lek Cesk Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Praha : Ceskoslovenska Lekarska Spolecnost
مواضيع طبية MeSH: Kidney Transplantation*, Graft Rejection/*etiology, Chronic Disease ; Graft Rejection/physiopathology ; Humans
مستخلص: Chronic rejection is the most common cause of the long term renal graft loss. It is characterized by luminal thickening and obliteration, interstitial sclerosis, glomerulosclerosis and tubular atrophy development. The pathology is still unclear. Alloantigen-dependent factors (acute rejection, HLA mismatch) and allograft-independent factors (ischaemia-reperfusion, hyperlipidaemia, hypertension, infection, nephrotoxicity, reduced nephron dose) have been implicated in the etiology of chronic rejection. As a result of these factors, endothelial cells are activated and express a variety of adhesion molecules, cytokines and growth factors. Lymphocytes and macrophages infiltrate the areas of local damage and express other cytokines and growth factors (TGF, bFGF, PDGF). In the next step, vascular smooth muscle cells proliferate and migrate from the media into the vascular intima and produce local extracellular matrix. Which factors are the most important and which mechanisms are the key for the development of chronic rejection are in the focus of ongoing research.
Number of References: 34
تواريخ الأحداث: Date Created: 20000404 Date Completed: 20000503 Latest Revision: 20061115
رمز التحديث: 20240627
PMID: 10746033
قاعدة البيانات: MEDLINE