دورية أكاديمية
Differential regulation of apoptosis in normal versus transformed mammary epithelium by lutein and retinoic acid.
| العنوان: | Differential regulation of apoptosis in normal versus transformed mammary epithelium by lutein and retinoic acid. |
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| المؤلفون: | Sumantran VN; Department of Internal Medicine and Comprehensive Cancer Center, University of Michigan, Ann Arbor 48109-0942, USA., Zhang R, Lee DS, Wicha MS |
| المصدر: | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology [Cancer Epidemiol Biomarkers Prev] 2000 Mar; Vol. 9 (3), pp. 257-63. |
| نوع المنشور: | Journal Article; Research Support, U.S. Gov't, P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 9200608 Publication Model: Print Cited Medium: Print ISSN: 1055-9965 (Print) Linking ISSN: 10559965 NLM ISO Abbreviation: Cancer Epidemiol Biomarkers Prev Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Philadelphia, PA : American Association for Cancer Research, c1991- |
| مواضيع طبية MeSH: | Antineoplastic Agents/*pharmacology , Apoptosis/*drug effects , Lutein/*pharmacology , Tretinoin/*pharmacology, Chemoprevention ; Female ; Gene Expression Regulation, Neoplastic ; Genes, p53/genetics ; Humans ; Simian virus 40/pathogenicity ; Tumor Cells, Cultured |
| مستخلص: | We examined the effects of all-trans retinoic acid (ATRA) and lutein (a nonprovitamin A carotenoid), on apoptosis and chemosensitivity in primary normal human mammary epithelial cells, SV40 transformed mammary cells, and MCF-7 human mammary carcinoma cells. ATRA and lutein selectively induced apoptosis in transformed but not normal human mammary cells. In addition, both compounds protected normal cells, but not transformed cells, from apoptosis induced by the chemotherapy agents etoposide and cisplatin. Furthermore, lutein and ATRA selectively increased the ratio of Bcl-xL:Bax protein expression in normal cells but not transformed mammary cells, suggesting a possible mechanism for selective modulation of apoptosis. The differential effects of lutein and ATRA on apoptotic pathways in normal versus transformed mammary epithelial cells may have important implications for chemoprevention and therapy. |
| معلومات مُعتمدة: | CA 61777-01 United States CA NCI NIH HHS; CA 66233 United States CA NCI NIH HHS |
| المشرفين على المادة: | 0 (Antineoplastic Agents) 5688UTC01R (Tretinoin) X72A60C9MT (Lutein) |
| تواريخ الأحداث: | Date Created: 20000406 Date Completed: 20000512 Latest Revision: 20131121 |
| رمز التحديث: | 20221213 |
| PMID: | 10750663 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1055-9965 |
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