دورية أكاديمية
Immunization with parasite-derived apical membrane antigen 1 or passive immunization with a specific monoclonal antibody protects BALB/c mice against lethal Plasmodium yoelii yoelii YM blood-stage infection.
العنوان: | Immunization with parasite-derived apical membrane antigen 1 or passive immunization with a specific monoclonal antibody protects BALB/c mice against lethal Plasmodium yoelii yoelii YM blood-stage infection. |
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المؤلفون: | Narum DL; Division of Parasitology, National Institute for Medical Research, London, NW7 1AA, United Kingdom. davidn@entremed.com, Ogun SA, Thomas AW, Holder AA |
المصدر: | Infection and immunity [Infect Immun] 2000 May; Vol. 68 (5), pp. 2899-906. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: American Society For Microbiology Country of Publication: United States NLM ID: 0246127 Publication Model: Print Cited Medium: Print ISSN: 0019-9567 (Print) Linking ISSN: 00199567 NLM ISO Abbreviation: Infect Immun Subsets: MEDLINE |
أسماء مطبوعة: | Publication: Washington, DC : American Society For Microbiology Original Publication: [Bethesda, Md.] American Society for Microbiology. |
مواضيع طبية MeSH: | Antibodies, Protozoan/*immunology , Antigens, Protozoan/*immunology , Antigens, Surface/*immunology , Malaria/*prevention & control , Malaria Vaccines/*immunology , Membrane Proteins/*immunology , Plasmodium yoelii/*immunology , Protozoan Proteins/*immunology, Animals ; Antibodies, Monoclonal/immunology ; Antibody Specificity ; Antigens, Protozoan/isolation & purification ; Antigens, Surface/isolation & purification ; Cross Reactions ; Female ; Fluorescent Antibody Technique ; Immunization, Passive/methods ; Immunoblotting ; Membrane Proteins/isolation & purification ; Mice ; Mice, Inbred BALB C ; Plasmodium falciparum/immunology ; Precipitin Tests ; Protozoan Proteins/isolation & purification ; Vaccination/methods |
مستخلص: | We have purified apical merozoite antigen 1 (AMA-1) from extracts of red blood cells infected with the rodent malaria parasite Plasmodium yoelii yoelii YM. When used to immunize mice, the protein induced a strong protective response against a challenge with the parasite. Monoclonal antibodies specific for P. yoelii yoelii AMA-1 were prepared, and one was very effective against the parasite on passive immunization. A second protein that appears to be located in the apical rhoptry organelles and associated with AMA-1 was identified. |
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معلومات مُعتمدة: | MC_U117532067 United Kingdom MRC_ Medical Research Council |
المشرفين على المادة: | 0 (Antibodies, Monoclonal) 0 (Antibodies, Protozoan) 0 (Antigens, Protozoan) 0 (Antigens, Surface) 0 (Malaria Vaccines) 0 (Membrane Proteins) 0 (Protozoan Proteins) 0 (apical membrane antigen I, Plasmodium) |
تواريخ الأحداث: | Date Created: 20000418 Date Completed: 20000613 Latest Revision: 20220129 |
رمز التحديث: | 20240513 |
مُعرف محوري في PubMed: | PMC97502 |
DOI: | 10.1128/IAI.68.5.2899-2906.2000 |
PMID: | 10768987 |
قاعدة البيانات: | MEDLINE |
تدمد: | 0019-9567 |
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DOI: | 10.1128/IAI.68.5.2899-2906.2000 |