دورية أكاديمية

Immunization with parasite-derived apical membrane antigen 1 or passive immunization with a specific monoclonal antibody protects BALB/c mice against lethal Plasmodium yoelii yoelii YM blood-stage infection.

التفاصيل البيبلوغرافية
العنوان: Immunization with parasite-derived apical membrane antigen 1 or passive immunization with a specific monoclonal antibody protects BALB/c mice against lethal Plasmodium yoelii yoelii YM blood-stage infection.
المؤلفون: Narum DL; Division of Parasitology, National Institute for Medical Research, London, NW7 1AA, United Kingdom. davidn@entremed.com, Ogun SA, Thomas AW, Holder AA
المصدر: Infection and immunity [Infect Immun] 2000 May; Vol. 68 (5), pp. 2899-906.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: American Society For Microbiology Country of Publication: United States NLM ID: 0246127 Publication Model: Print Cited Medium: Print ISSN: 0019-9567 (Print) Linking ISSN: 00199567 NLM ISO Abbreviation: Infect Immun Subsets: MEDLINE
أسماء مطبوعة: Publication: Washington, DC : American Society For Microbiology
Original Publication: [Bethesda, Md.] American Society for Microbiology.
مواضيع طبية MeSH: Antibodies, Protozoan/*immunology , Antigens, Protozoan/*immunology , Antigens, Surface/*immunology , Malaria/*prevention & control , Malaria Vaccines/*immunology , Membrane Proteins/*immunology , Plasmodium yoelii/*immunology , Protozoan Proteins/*immunology, Animals ; Antibodies, Monoclonal/immunology ; Antibody Specificity ; Antigens, Protozoan/isolation & purification ; Antigens, Surface/isolation & purification ; Cross Reactions ; Female ; Fluorescent Antibody Technique ; Immunization, Passive/methods ; Immunoblotting ; Membrane Proteins/isolation & purification ; Mice ; Mice, Inbred BALB C ; Plasmodium falciparum/immunology ; Precipitin Tests ; Protozoan Proteins/isolation & purification ; Vaccination/methods
مستخلص: We have purified apical merozoite antigen 1 (AMA-1) from extracts of red blood cells infected with the rodent malaria parasite Plasmodium yoelii yoelii YM. When used to immunize mice, the protein induced a strong protective response against a challenge with the parasite. Monoclonal antibodies specific for P. yoelii yoelii AMA-1 were prepared, and one was very effective against the parasite on passive immunization. A second protein that appears to be located in the apical rhoptry organelles and associated with AMA-1 was identified.
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معلومات مُعتمدة: MC_U117532067 United Kingdom MRC_ Medical Research Council
المشرفين على المادة: 0 (Antibodies, Monoclonal)
0 (Antibodies, Protozoan)
0 (Antigens, Protozoan)
0 (Antigens, Surface)
0 (Malaria Vaccines)
0 (Membrane Proteins)
0 (Protozoan Proteins)
0 (apical membrane antigen I, Plasmodium)
تواريخ الأحداث: Date Created: 20000418 Date Completed: 20000613 Latest Revision: 20220129
رمز التحديث: 20240513
مُعرف محوري في PubMed: PMC97502
DOI: 10.1128/IAI.68.5.2899-2906.2000
PMID: 10768987
قاعدة البيانات: MEDLINE
الوصف
تدمد:0019-9567
DOI:10.1128/IAI.68.5.2899-2906.2000