دورية أكاديمية
Truncation of blood curves to enhance imaging and therapy with monoclonal antibodies.
| العنوان: | Truncation of blood curves to enhance imaging and therapy with monoclonal antibodies. |
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| المؤلفون: | Williams LE; Division of Radiology, City of Hope National Medical Center, Beckman Research Institute, Duarte, California 91010, USA. lwilliams@coh.org, Liu A, Wu AM, Yazaki PJ, Yamauchi DM, Lopatin G, Raubitschek AA, Wong JY |
| المصدر: | Medical physics [Med Phys] 2000 May; Vol. 27 (5), pp. 988-94. |
| نوع المنشور: | Journal Article; Research Support, U.S. Gov't, P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: John Wiley and Sons, Inc Country of Publication: United States NLM ID: 0425746 Publication Model: Print Cited Medium: Print ISSN: 0094-2405 (Print) Linking ISSN: 00942405 NLM ISO Abbreviation: Med Phys Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2017- : Hoboken, NJ : John Wiley and Sons, Inc. Original Publication: Lancaster, Pa., Published for the American Assn. of Physicists in Medicine by the American Institute of Physics. |
| مواضيع طبية MeSH: | Radioimmunodetection* , Radioimmunotherapy*, Antibodies, Monoclonal/*therapeutic use , Radiopharmaceuticals/*blood, Animals ; Antibodies, Monoclonal/blood ; Biophysical Phenomena ; Biophysics ; Humans ; Mice ; Models, Biological ; Neoplasms/blood ; Neoplasms/diagnostic imaging ; Neoplasms/radiotherapy ; Radiopharmaceuticals/therapeutic use |
| مستخلص: | Targeting of monoclonal antibody (Mab) to solid tumor sites is a function of the blood curve of activity versus time. It has been suggested that the blood curve be artificially reduced to approach zero so that the contrast between tumor and blood uptake is maximized. We analyzed tumor uptake as a function of the time tc of blood curve truncation. By using a convolution approach, we were able to find the optimal times for setting the blood curve to zero in either diagnostic or therapeutic animal examples. Two iodinated cT84.66 anti-CEA engineered fragments, diabody and minibody, were considered using previous data from nude mouse studies involving the LS174T colorectal tumor model. Figures of merit (FOMs) were used to compare ordinary and truncated blood curves and their associated tumor accumulations. Using a 1231 label, it was seen that the appropriate time for diagnostic truncation occurred when tumor uptake, as measured, was a maximum. The corresponding point for therapy (with 1311 as a label) was at infinite time. We also demonstrated that the use of traditional indices led to ambiguities in the choice of truncation times. The traditional therapy index, the ratio of the integral of the tumor uptake to the integral of the blood uptake, was found to be a numerical constant independent of tc. This ratio was proved to be the integral of the tumor impulse response function. Use of such convolution techniques to assess truncation of the perfused material is probably also applicable to multistep processes as well as to lesion targeting with other tumor-specific pharmaceuticals. |
| معلومات مُعتمدة: | 33572 United States PHS HHS; CA43904 United States CA NCI NIH HHS |
| المشرفين على المادة: | 0 (Antibodies, Monoclonal) 0 (Radiopharmaceuticals) |
| تواريخ الأحداث: | Date Created: 20000607 Date Completed: 20000925 Latest Revision: 20170214 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1118/1.598963 |
| PMID: | 10841401 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0094-2405 |
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| DOI: | 10.1118/1.598963 |