دورية أكاديمية
Rat somatosensory cerebropontocerebellar pathways: spatial relationships of the somatotopic map of the primary somatosensory cortex are preserved in a three-dimensional clustered pontine map.
| العنوان: | Rat somatosensory cerebropontocerebellar pathways: spatial relationships of the somatotopic map of the primary somatosensory cortex are preserved in a three-dimensional clustered pontine map. |
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| المؤلفون: | Leergaard TB; Department of Anatomy, Institute of Basic Medical Sciences, University of Oslo, N-0317 Oslo, Norway., Lyngstad KA, Thompson JH, Taeymans S, Vos BP, De Schutter E, Bower JM, Bjaalie JG |
| المصدر: | The Journal of comparative neurology [J Comp Neurol] 2000 Jun 26; Vol. 422 (2), pp. 246-66. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Liss Country of Publication: United States NLM ID: 0406041 Publication Model: Print Cited Medium: Print ISSN: 0021-9967 (Print) Linking ISSN: 00219967 NLM ISO Abbreviation: J Comp Neurol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2003-> : Hoboken, N.J. : Wiley-Liss Original Publication: Philadelphia Wistar Institute of Anatomy and Biology |
| مواضيع طبية MeSH: | Cerebellum/*cytology , Cerebellum/*physiology , Neural Pathways/*cytology , Neural Pathways/*physiology , Pons/*cytology , Pons/*physiology , Somatosensory Cortex/*cytology , Somatosensory Cortex/*physiology, Animals ; Biotin/analogs & derivatives ; Brain Mapping ; Dextrans ; Electrophysiology ; Female ; Fluorescent Dyes ; Image Processing, Computer-Assisted ; Phytohemagglutinins ; Presynaptic Terminals/physiology ; Presynaptic Terminals/ultrastructure ; Rats ; Rats, Sprague-Dawley ; Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate |
| مستخلص: | In the primary somatosensory cortex (SI), the body surface is mapped in a relatively continuous fashion, with adjacent body regions represented in adjacent cortical domains. In contrast, somatosensory maps found in regions of the cerebellar hemispheres, which are influenced by the SI through a monosynaptic link in the pontine nuclei, are discontinuous ("fractured") in organization. To elucidate this map transformation, the authors studied the organization of the first link in the SI-cerebellar pathway, the SI-pontine projection. After injecting anterograde axonal tracers into electrophysiologically defined parts of the SI, three-dimensional reconstruction and computer-graphic visualization techniques were used to analyze the spatial distribution of labeled fibers. Several target regions in the pontine nuclei were identified for each major body representation. The labeled axons formed sharply delineated clusters that were distributed in an inside-out, shell-like fashion. Upper lip and other perioral representations were located in a central core, whereas extremity and trunk representations were found more externally. The multiple clusters suggest that the pontine nuclei contain several representations of the SI map. Within each representation, the spatial relationships of the SI map are largely preserved. This corticopontine projection pattern is compatible with recently proposed principles for the establishment of subcortical topographic patterns during development. The largely preserved spatial relationships in the pontine somatotopic map also suggest that the transformation from an organized topography in SI to a fractured map in the cerebellum takes place primarily in the mossy fiber pontocerebellar projection. (Copyright 2000 Wiley-Liss, Inc.) |
| معلومات مُعتمدة: | NS37109 United States NS NINDS NIH HHS |
| المشرفين على المادة: | 0 (Dextrans) 0 (Fluorescent Dyes) 0 (Phytohemagglutinins) 0 (Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate) 0 (biotinylated dextran amine) 0 (leukoagglutinins, plants) 6SO6U10H04 (Biotin) |
| تواريخ الأحداث: | Date Created: 20000608 Date Completed: 20000802 Latest Revision: 20190905 |
| رمز التحديث: | 20240513 |
| DOI: | 10.1002/(sici)1096-9861(20000626)422:2<246::aid-cne7>3.0.co;2-r |
| PMID: | 10842230 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0021-9967 |
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| DOI: | 10.1002/(sici)1096-9861(20000626)422:2<246::aid-cne7>3.0.co;2-r |