دورية أكاديمية
أعرض في EDS

A bcl-xS adenovirus selectively induces apoptosis in transformed cells compared to normal mammary cells.

التفاصيل البيبلوغرافية
العنوان: A bcl-xS adenovirus selectively induces apoptosis in transformed cells compared to normal mammary cells.
المؤلفون: Sumantran VN; Department of Internal Medicine, University of Michigan Comprehensive Cancer Center, University of Michigan, Ann Arbor 48109-0942, USA., Lee DS, Woods Ignatoski KM, Ethier SP, Wicha MS
المصدر: Neoplasia (New York, N.Y.) [Neoplasia] 2000 May-Jun; Vol. 2 (3), pp. 251-60.
نوع المنشور: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 100886622 Publication Model: Print Cited Medium: Print ISSN: 1522-8002 (Print) Linking ISSN: 14765586 NLM ISO Abbreviation: Neoplasia Subsets: MEDLINE
أسماء مطبوعة: Publication: 2014- : [Amsterdam] : Elsevier
Original Publication: New York, NY : Stockton Press, c1999-
مواضيع طبية MeSH: Apoptosis*, Adenoviridae/*genetics , Mammary Glands, Animal/*cytology , Mammary Neoplasms, Experimental/*therapy , Proto-Oncogene Proteins c-bcl-2/*physiology, Animals ; Cell Line ; Cell Transformation, Neoplastic ; Fluorouracil/pharmacology ; Genes, myc ; Humans ; Paclitaxel/pharmacology ; Proto-Oncogene Proteins c-bcl-2/genetics ; Receptor, ErbB-2/physiology ; bcl-X Protein
مستخلص: Oncogenes which drive the cell cycle, such as c-myc, can sensitize cells to apoptosis. This suggests the possibility that the expression of genes such as bcl-2 or bcl-xL is required to inhibit apoptosis induced by oncogene expression. We hypothesized that inhibition of Bcl-2/Bcl-xL by the pro-apoptotic Bcl-xS protein, would result in selective induction of apoptosis in mammary carcinoma cells compared to their nontransformed counterparts. Therefore, we compared the effects of Bcl-xS expression delivered by a bcl-xS adenovirus (bcl-xS-Adv) vector, on viability and apoptosis of nontransformed versus transformed mammary epithelial cells. We report that c-myc-transformed murine mammary cells are extremely sensitive to apoptosis induced by the bcl-xS adenovirus (bcl-xS-Adv) vector, whereas immortalized, nontransformed murine mammary cells are relatively resistant to apoptosis induced by this vector. Likewise, human mammary epithelial cells transduced with c-erbB-2 were more sensitive to apoptosis induced by the bcl-xS vector than the nontransformed parental cells. Similar results were obtained when we tested the effects of bcl-xS adenoviral infection on primary normal human mammary epithelial cells and SUM-190 PT cells, (a c-erbB-2 over-expressing human mammary carcinoma cell line) grown on Matrigel. These data are consistent with the hypothesis that inhibition of Bcl-2/Bcl-xL can result in selective killing of cancer cells compared to their nontransformed counterparts.
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معلومات مُعتمدة: P01 CA075136 United States CA NCI NIH HHS; 1PO1 CA75136-01A1 United States CA NCI NIH HHS
المشرفين على المادة: 0 (BCL2L1 protein, human)
0 (Proto-Oncogene Proteins c-bcl-2)
0 (bcl-X Protein)
EC 2.7.10.1 (Receptor, ErbB-2)
P88XT4IS4D (Paclitaxel)
U3P01618RT (Fluorouracil)
تواريخ الأحداث: Date Created: 20000810 Date Completed: 20000817 Latest Revision: 20190607
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC1507566
DOI: 10.1038/sj.neo.7900084
PMID: 10935511
قاعدة البيانات: MEDLINE
الوصف
تدمد:1522-8002
DOI:10.1038/sj.neo.7900084