دورية أكاديمية
Competence of the human host as a reservoir for Leishmania chagasi.
| العنوان: | Competence of the human host as a reservoir for Leishmania chagasi. |
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| المؤلفون: | Costa CH; Hospital de Doenças Infecto-Contagiosas, 64001-450, Teresina-PI, Brazil. costa@ranet.com.br, Gomes RB, Silva MR, Garcez LM, Ramos PK, Santos RS, Shaw JJ, David JR, Maguire JH |
| المصدر: | The Journal of infectious diseases [J Infect Dis] 2000 Sep; Vol. 182 (3), pp. 997-1000. Date of Electronic Publication: 2000 Aug 17. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: United States NLM ID: 0413675 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0022-1899 (Print) Linking ISSN: 00221899 NLM ISO Abbreviation: J Infect Dis Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Jan. 2011- : Oxford : Oxford University Press Original Publication: 1904-2010 : Chicago, IL : University of Chicago Press |
| مواضيع طبية MeSH: | Leishmania*, Leishmaniasis, Visceral/*transmission, Adolescent ; Animals ; Brazil ; Child ; Child, Preschool ; Disease Reservoirs ; Dogs ; Enzyme-Linked Immunosorbent Assay ; Humans ; Infant ; Polymerase Chain Reaction ; Psychodidae |
| مستخلص: | The failure of control programs for visceral leishmaniasis (VL) that depend on elimination of infected dogs suggests that other reservoir hosts may participate in the transmission cycle. To determine whether persons infected with Leishmania chagasi can infect the vector sand fly, laboratory-reared Lutzomyia longipalpis were allowed to feed on Brazilian subjects with active, cured, and asymptomatic VL and on asymptomatic residents of houses of persons with active VL. Of 3747 insects that had fed, 26 acquired infection from 11 of the 44 persons with active VL, but none acquired infection from the 137 asymptomatic persons. Among persons <4 years old with active VL, a history of diarrhea and higher peripheral blood neutrophil counts were independent predictors of infectivity. Further experiments using larger numbers of insects are necessary to evaluate the reservoir competence of persons with asymptomatic infections, who represent a large segment of the population of several Brazilian cities. |
| معلومات مُعتمدة: | AI16303 United States AI NIAID NIH HHS |
| تواريخ الأحداث: | Date Created: 20000819 Date Completed: 20001103 Latest Revision: 20071114 |
| رمز التحديث: | 20240513 |
| DOI: | 10.1086/315795 |
| PMID: | 10950806 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0022-1899 |
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| DOI: | 10.1086/315795 |