دورية أكاديمية
Moderate intervention with carotenoid-rich vegetable products reduces lipid peroxidation in men.
| العنوان: | Moderate intervention with carotenoid-rich vegetable products reduces lipid peroxidation in men. |
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| المؤلفون: | Bub A; Institute of Nutritional Physiology, Federal Research Centre for Nutrition, D-76131 Karlsruhe, Germany., Watzl B, Abrahamse L, Delincée H, Adam S, Wever J, Müller H, Rechkemmer G |
| المصدر: | The Journal of nutrition [J Nutr] 2000 Sep; Vol. 130 (9), pp. 2200-6. |
| نوع المنشور: | Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 0404243 Publication Model: Print Cited Medium: Print ISSN: 0022-3166 (Print) Linking ISSN: 00223166 NLM ISO Abbreviation: J Nutr Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2023- : [New York, NY] : Elsevier Original Publication: 1928-1933 : Springfield, Ill. : C. C. Thomas |
| مواضيع طبية MeSH: | Vegetables*, Antioxidants/*metabolism , Carotenoids/*pharmacology , Lipid Peroxidation/*drug effects, Adult ; Analysis of Variance ; Ascorbic Acid/blood ; Carotenoids/administration & dosage ; Carotenoids/analysis ; Carotenoids/blood ; Diet ; Food Analysis ; Glutathione/blood ; Humans ; Lipoproteins, LDL/analysis ; Male |
| مستخلص: | Because of their antioxidant properties, carotenoids may have beneficial effects in preventing cancer and cardiovascular disease. However, in humans consuming carotenoid-rich vegetables, data concerning the antioxidant effects of carotenoids are rather scarce. A human intervention trial was conducted, therefore, to determine whether a moderately increased consumption of carotenoid-rich vegetables would influence the antioxidant status in 23 healthy men. This short-term feeding study lasted 8 wk during which the men consumed a low carotenoid diet. A 2-wk low carotenoid period was followed by daily consumption of 330 mL tomato juice, then by 330 mL carrot juice and then by 10 g of spinach powder, each for 2 wk. Antioxidant status [water-soluble antioxidants in serum, ferric reducing ability of plasma (FRAP) and antioxidant enzyme activities] and lipid peroxidation (plasma malondialdehyde and ex vivo oxidation of LDL) were determined. In a subgroup of 10 men, lipoprotein carotenoids were measured. The consumption of carotenoid-rich vegetables significantly increased selected carotenoids in lipoproteins but had only minor effects on their relative distribution pattern. Tomato juice consumption reduced plasma thiobarbituric acid reactive substances (TBARS) by 12% (P: < 0.05) and lipoprotein oxidizability in terms of an increased lag time (18%, P: < 0.05). Carrot juice and spinach powder had no effect on lipid peroxidation. Water-soluble antioxidants, FRAP, glutathione peroxidase and reductase activities did not change during any study period. In evaluating the low carotenoid diet, we conclude that the additional consumption of carotenoid-rich vegetable products enhanced lipoprotein carotenoid concentrations, but only tomato juice reduced LDL oxidation in healthy men. |
| المشرفين على المادة: | 0 (Antioxidants) 0 (Lipoproteins, LDL) 36-88-4 (Carotenoids) GAN16C9B8O (Glutathione) PQ6CK8PD0R (Ascorbic Acid) |
| تواريخ الأحداث: | Date Created: 20000826 Date Completed: 20001003 Latest Revision: 20220408 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1093/jn/130.9.2200 |
| PMID: | 10958813 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0022-3166 |
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| DOI: | 10.1093/jn/130.9.2200 |