التفاصيل البيبلوغرافية
| العنوان: |
Glutamatergic influences on the nucleus paragigantocellularis: contribution to performance in avoidance and spatial memory tasks. |
| المؤلفون: |
Clayton EC; Department of Psychology, University of Virginia, Charlottesville 22904-4400, USA., Williams CL |
| المصدر: |
Behavioral neuroscience [Behav Neurosci] 2000 Aug; Vol. 114 (4), pp. 707-12. |
| نوع المنشور: |
Journal Article; Research Support, U.S. Gov't, P.H.S. |
| اللغة: |
English |
| بيانات الدورية: |
Publisher: American Psychological Association Country of Publication: United States NLM ID: 8302411 Publication Model: Print Cited Medium: Print ISSN: 0735-7044 (Print) Linking ISSN: 07357044 NLM ISO Abbreviation: Behav Neurosci Subsets: MEDLINE |
| أسماء مطبوعة: |
Original Publication: Washington, D.C. : American Psychological Association, [c1983- |
| مواضيع طبية MeSH: |
Avoidance Learning/*physiology , Glutamic Acid/*physiology , Locus Coeruleus/*physiology , Mental Recall/*physiology , Orientation/*physiology, Afferent Pathways/physiology ; Animals ; Arousal/physiology ; Brain Mapping ; Long-Term Potentiation/physiology ; Male ; Maze Learning/physiology ; Nerve Net/physiology ; Rats ; Rats, Sprague-Dawley ; Retention, Psychology/physiology |
| مستخلص: |
Stimulation of the locus coeruleus (LC) and the subsequent release of norepinephrine contribute to memory consolidation processes. Excitatory input to the LC is derived primarily from neurons in the nucleus paragigantocellularis (PGi). The authors examined the effects of activating the pathway between PGi and the LC on memory. Rats received vehicle or the excitatory amino acid glutamate (25, 50, or 100 nmol/0.5 microl) into PGi after training in an inhibitory avoidance (IA) or delayed matching-to-sample (DMS) task. Rats given the 100-nmol dose had significantly longer retention latencies on a 48-hr IA retention test. Rats treated with the 50- or 100-nmol dose made significantly more correct responses than controls on an 18-hr DMS retention test. Results suggest that encoding and storage of memory for emotional and spatial events may be enhanced by activation of neuronal circuits afferent to the LC. |
| معلومات مُعتمدة: |
MHO14505-01 United States MH NIMH NIH HHS |
| المشرفين على المادة: |
3KX376GY7L (Glutamic Acid) |
| تواريخ الأحداث: |
Date Created: 20000826 Date Completed: 20010102 Latest Revision: 20191210 |
| رمز التحديث: |
20231215 |
| DOI: |
10.1037//0735-7044.114.4.707 |
| PMID: |
10959529 |
| قاعدة البيانات: |
MEDLINE |
