دورية أكاديمية
Thyroid stimulating hormone levels in cord blood are not influenced by non-thyroidal mothers' diseases.
| العنوان: | Thyroid stimulating hormone levels in cord blood are not influenced by non-thyroidal mothers' diseases. |
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| المؤلفون: | Ward LS; Department of Medicine, Faculty of Medical Sciences, State University of Campinas, Campinas, Brazil., Kunii IS, de Barros Maciel RM |
| المصدر: | Sao Paulo medical journal = Revista paulista de medicina [Sao Paulo Med J] 2000 Sep 07; Vol. 118 (5), pp. 144-7. |
| نوع المنشور: | Clinical Trial; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Associação Paulista de Medicina Country of Publication: Brazil NLM ID: 100897261 Publication Model: Print Cited Medium: Print ISSN: 1516-3180 (Print) Linking ISSN: 15163180 NLM ISO Abbreviation: Sao Paulo Med J Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: São Paulo, S.P., Brazil : Associação Paulista de Medicina, [1994- |
| مواضيع طبية MeSH: | Pregnancy Complications*, Fetal Blood/*chemistry , Hypothyroidism/*diagnosis , Thyrotropin/*blood, Acquired Immunodeficiency Syndrome ; Congenital Hypothyroidism ; Diabetes Mellitus ; Female ; Follow-Up Studies ; Heart Diseases ; Humans ; Infant, Newborn ; Male ; Mothers ; Neonatal Screening ; Pre-Eclampsia ; Pregnancy ; Prospective Studies |
| مستخلص: | Context: Screening programs not only offer the opportunity to trace and treat almost all cases of congenital hypothyroidism but also mean large savings to the health system. However, carefully planned strategies are necessary to extend their benefits and reduce costs. Objective: To determine the possible influence of maternal diseases that affect maternal-fetal placenta dynamics on primary thyroid stimulating hormone (TSH) screening for congenital hypothyroidism. Design: Prospective non-randomized clinical trial with at least 3 months of follow-up. Setting: A public university referral center [CAISM/Hospital das Clínicas, Faculty of Medicine, University of Campinas, Campinas, SP]. Participants: 415 neonates divided into 5 groups: eighty-three infants born from cardiac mothers; 98 from mothers that had toxemia; 54 of the mothers had diabetes mellitus; 40 were HIV positive and 140 had no diseases. Intervention: All newborns had cord blood samples collected on filter paper at birth. Main Measurements: TSH was measured from dried blood spots using a homemade immunofluorescence assay (sensitivity in dried blood spots = 0.1 mU/L). Results: There was no significant difference in the mean TSH levels among the 5 groups. Moreover, TSH levels were around 5 mU/L in 48% of the newborns, indicating that our region is severely deficient in iodine. Conclusions: Our results indicate that primary TSH screening programs using cord blood are not affected by maternal diseases. We suggest that, besides its technical advantages over heel punctures with T4 primary approaches, neonatal screening using primary cord blood TSH may also be used as a monitoring tool for evaluation and control of iodine deficiency disorders (IDD). |
| المشرفين على المادة: | 9002-71-5 (Thyrotropin) |
| تواريخ الأحداث: | Date Created: 20001006 Date Completed: 20001221 Latest Revision: 20190921 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1590/s1516-31802000000500006 |
| PMID: | 11018848 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1516-3180 |
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| DOI: | 10.1590/s1516-31802000000500006 |