التفاصيل البيبلوغرافية
| العنوان: |
Genetic syndromes and genetic tests in colorectal cancer. |
| المؤلفون: |
Calland JF; Department of Surgery, University of Virginia Health Systems, Charlottesville 22908-0708, USA., Adams RB, DePrince K, Foley EF, Powell SM |
| المصدر: |
Seminars in gastrointestinal disease [Semin Gastrointest Dis] 2000 Oct; Vol. 11 (4), pp. 207-18. |
| نوع المنشور: |
Journal Article; Review |
| اللغة: |
English |
| بيانات الدورية: |
Publisher: W.B. Saunders Country of Publication: United States NLM ID: 9100391 Publication Model: Print Cited Medium: Print ISSN: 1049-5118 (Print) Linking ISSN: 10495118 NLM ISO Abbreviation: Semin Gastrointest Dis Subsets: MEDLINE |
| أسماء مطبوعة: |
Original Publication: Philadelphia, PA : W.B. Saunders, 1990- |
| مواضيع طبية MeSH: |
Genetic Testing*, Colorectal Neoplasms/*diagnosis , Colorectal Neoplasms/*genetics, Adenomatous Polyposis Coli/diagnosis ; Adenomatous Polyposis Coli/genetics ; Colorectal Neoplasms, Hereditary Nonpolyposis/diagnosis ; Colorectal Neoplasms, Hereditary Nonpolyposis/genetics ; Genetic Predisposition to Disease ; Humans ; Peutz-Jeghers Syndrome/diagnosis ; Peutz-Jeghers Syndrome/genetics |
| مستخلص: |
Our understanding of the biology of colon cancer has matured to the point that it is a useful general paradigm for understanding solid tumor development. Recent advances provide insight into the genetic alterations underlying the development of colon cancer. These insights provide unique opportunities for genetic testing in predisposed, asymptomatic patients that can direct screening efforts and their clinical management. This review examines several inherited colon cancer predispositions, well described clinically for a century, that are now amenable to genetic testing. Additional discussion focuses on colon cancer predisposition traits that occur with high frequency but low penetrance characteristics. Finally, genetic tests for tumor markers that potentially have prognostic or therapeutic implications are reviewed. |
| Number of References: |
62 |
| تواريخ الأحداث: |
Date Created: 20001101 Date Completed: 20010208 Latest Revision: 20091119 |
| رمز التحديث: |
20221213 |
| PMID: |
11057948 |
| قاعدة البيانات: |
MEDLINE |
