دورية أكاديمية
Primary, localized vulvar B-cell lymphoma expressing CD44 variant 6 but not cadherins. A case report.
| العنوان: | Primary, localized vulvar B-cell lymphoma expressing CD44 variant 6 but not cadherins. A case report. |
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| المؤلفون: | Iczkowski KA; Department of Pathology, Reading Hospital, West Reading, Pennsylvania, USA. iczkowski@pathology.ufl.edu, Han AC, Edelson MI, Rosenblum NG |
| المصدر: | The Journal of reproductive medicine [J Reprod Med] 2000 Oct; Vol. 45 (10), pp. 853-6. |
| نوع المنشور: | Case Reports; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Science Printers and Publishers, Inc Country of Publication: United States NLM ID: 0173343 Publication Model: Print Cited Medium: Print ISSN: 0024-7758 (Print) Linking ISSN: 00247758 NLM ISO Abbreviation: J Reprod Med Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <1999->: St. Louis, MO : Science Printers and Publishers, Inc Original Publication: Chicago, Journal of Reproductive Medicine, inc. [etc.] |
| مواضيع طبية MeSH: | Hyaluronan Receptors/*metabolism , Lymphoma, B-Cell/*metabolism , Lymphoma, B-Cell/*pathology , Vulvar Neoplasms/*metabolism , Vulvar Neoplasms/*pathology, Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Cadherins/metabolism ; Diagnosis, Differential ; Female ; Humans ; Lymphoma, B-Cell/drug therapy ; Lymphoma, B-Cell/surgery ; Middle Aged ; Vulvar Neoplasms/drug therapy ; Vulvar Neoplasms/surgery |
| مستخلص: | Background: Primary extranodal lymphoma of the vulva is rare, with only 17 prior cases reported. Its immunohistochemical profile has not been characterized beyond B- or T-cell phenotype. Case: A 64-year-old, white woman presented with a nontender enlargement of the right labium minus and labium majus. Bilateral vulvar punch biopsies revealed an infiltrate of neoplastic lymphocytes that filled the reticular dermis and extended down to the subcutaneous fat. Lymphoma cells were positive for CD20 and expressed CD43 in an aberrant manner. The tumor was examined for adhesion protein expression. There was expression of CD44 standard and variant 6 but not of E-, N- or P-cadherin. No systemic spread of this rare lymphoma was evident after one year. Conclusion: Adhesion protein expression in primary vulvar lymphoma may have prognostic implications. |
| المشرفين على المادة: | 0 (Cadherins) 0 (Hyaluronan Receptors) |
| تواريخ الأحداث: | Date Created: 20001115 Date Completed: 20010315 Latest Revision: 20171116 |
| رمز التحديث: | 20240627 |
| PMID: | 11077639 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0024-7758 |
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