دورية أكاديمية
Prognostic impact of bulky mediastinal lymph nodes (N2>2.5 cm) in patients with locally advanced non-small-cell lung cancer (LA-NSCLC) treated with platinum-based induction chemotherapy.
| العنوان: | Prognostic impact of bulky mediastinal lymph nodes (N2>2.5 cm) in patients with locally advanced non-small-cell lung cancer (LA-NSCLC) treated with platinum-based induction chemotherapy. |
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| المؤلفون: | Maurel J; Medical Oncology Service, University Hospital Miguel Servet, Av. Isabel La Catolica 1-3, Zaragoza, Spain., Martinez-Trufero J, Artal A, Martin C, Puertolas T, Zorrrilla M, Herrero A, Antón A, Rosell R |
| المصدر: | Lung cancer (Amsterdam, Netherlands) [Lung Cancer] 2000 Nov; Vol. 30 (2), pp. 107-16. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Scientific Publishers Country of Publication: Ireland NLM ID: 8800805 Publication Model: Print Cited Medium: Print ISSN: 0169-5002 (Print) Linking ISSN: 01695002 NLM ISO Abbreviation: Lung Cancer Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Limerick : Elsevier Scientific Publishers Original Publication: Amsterdam, The Netherlands : Elsevier, c1985- |
| مواضيع طبية MeSH: | Antineoplastic Agents/*therapeutic use , Carcinoma, Non-Small-Cell Lung/*diagnosis , Lung Neoplasms/*diagnosis , Lymph Nodes/*pathology , Platinum Compounds/*therapeutic use, Adult ; Aged ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/mortality ; Carcinoma, Non-Small-Cell Lung/secondary ; Female ; Humans ; Lung Neoplasms/drug therapy ; Lung Neoplasms/mortality ; Lung Neoplasms/pathology ; Male ; Mediastinum/pathology ; Middle Aged ; Prognosis ; Retrospective Studies ; Survival Analysis ; Treatment Outcome |
| مستخلص: | A group of 70 patients with locally advanced non-small-cell lung cancer (LA-NSCLC), treated in different phase II-III trials with platinum-based chemotherapy in two institutions, have been evaluated to identify potential baseline prognostic factors predicting their survival. The eligibility criteria were patients with stage IIIA (N2)-IIIB, Eastern Cooperative Oncology Group performance status 0.1 and less than 5% weight loss. All 37 patients with stage IIIA(N2) were treated with platinum-based induction chemotherapy followed by surgery plus radiotherapy if no progression was observed. The other 33 patients with stage IIIB were treated with platinum-based induction chemotherapy followed by conventional fractionation radiotherapy if no progression was observed. The overall response rate to induction chemotherapy was 40%. Median survival of the 70 patients was 13 months, with a 4-year survival of 15%. At univariate analysis, two prognostic factors correlated with survival: partial or complete response to induction chemotherapy (P<0.00001) and bulky mediastinal lymph nodes (N2>2.5 cm) (P=0.03). At multivariate analysis, only the response to induction chemotherapy retained statistical significance (P=0.00001). Randomized well-balanced prospective trials considering initially mediastinal N2 node size are needed to clearly establish the role of chemotherapy, surgery and radiotherapy in LA-NSCLC. |
| المشرفين على المادة: | 0 (Antineoplastic Agents) 0 (Platinum Compounds) |
| تواريخ الأحداث: | Date Created: 20001122 Date Completed: 20010125 Latest Revision: 20190921 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/s0169-5002(00)00128-8 |
| PMID: | 11086204 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0169-5002 |
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| DOI: | 10.1016/s0169-5002(00)00128-8 |