دورية أكاديمية
Disparity in neurotransmitter release probability among competing inputs during neuromuscular synapse elimination.
| العنوان: | Disparity in neurotransmitter release probability among competing inputs during neuromuscular synapse elimination. |
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| المؤلفون: | Kopp DM; Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6074, USA., Perkel DJ, Balice-Gordon RJ |
| المصدر: | The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2000 Dec 01; Vol. 20 (23), pp. 8771-9. |
| نوع المنشور: | Journal Article; Research Support, U.S. Gov't, P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: Society for Neuroscience Country of Publication: United States NLM ID: 8102140 Publication Model: Print Cited Medium: Internet ISSN: 1529-2401 (Electronic) Linking ISSN: 02706474 NLM ISO Abbreviation: J Neurosci Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Washington, DC : Society for Neuroscience Original Publication: [Baltimore, Md.] : The Society, c1981- |
| مواضيع طبية MeSH: | Neuromuscular Junction/*metabolism , Neurotransmitter Agents/*metabolism , Synapses/*metabolism, Animals ; Animals, Newborn ; Axons/physiology ; Calcium/metabolism ; Electric Stimulation ; Electrophysiology ; In Vitro Techniques ; Magnesium/metabolism ; Membrane Potentials/physiology ; Mice ; Models, Neurological ; Motor Neurons/cytology ; Motor Neurons/metabolism ; Muscle, Skeletal/innervation ; Neuromuscular Junction/growth & development ; Regression Analysis ; Synaptic Transmission/physiology |
| مستخلص: | Competition among the several motor axons transiently innervating neonatal muscle fibers results in an increasing disparity in the quantal content and synaptic territory of each competitor, culminating in the permanent loss of all but one axon from neuromuscular junctions. We asked whether differences in the probability of neurotransmitter release also contribute to the increasing disparity in quantal content among competing inputs, and when in the process of competition changes in release probability become apparent. To address these questions, intracellular recordings were made from dually innervated neonatal mouse soleus muscle fibers, and quantal content and paired-pulse facilitation were evaluated for each input. At short interpulse intervals, paired-pulse facilitation was significantly higher for the weaker input with the smaller quantal content than the stronger input with the larger quantal content. Because neurotransmitter release probability across all release sites is inversely related to the extent of facilitation observed after paired-pulse stimulation, this result suggests that release probability is lower for weak compared with strong inputs innervating the same junction. A disparity in the probability of neurotransmitter release thus contributes to the disparity in quantal content that occurs during synaptic competition. Together, this work suggests that an input incapable of sustaining a high release probability may be at a competitive disadvantage for synaptic maintenance. |
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| معلومات مُعتمدة: | F32 NS010624 United States NS NINDS NIH HHS; NS38517 United States NS NINDS NIH HHS; NS10624 United States NS NINDS NIH HHS |
| المشرفين على المادة: | 0 (Neurotransmitter Agents) I38ZP9992A (Magnesium) SY7Q814VUP (Calcium) |
| تواريخ الأحداث: | Date Created: 20000111 Date Completed: 20010208 Latest Revision: 20240720 |
| رمز التحديث: | 20240720 |
| مُعرف محوري في PubMed: | PMC6773052 |
| PMID: | 11102485 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1529-2401 |
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