دورية أكاديمية
أعرض في EDS

Phenotypic markers as risk factors in schizophrenia: neurocognitive functions.

التفاصيل البيبلوغرافية
العنوان: Phenotypic markers as risk factors in schizophrenia: neurocognitive functions.
المؤلفون: Michie PT; The University of Western Australia, Perth, Australia. pat@psy.uwa.edu.au, Kent A, Stienstra R, Castine R, Johnston J, Dedman K, Wichmann H, Box J, Rock D, Rutherford E, Jablensky A
المصدر: The Australian and New Zealand journal of psychiatry [Aust N Z J Psychiatry] 2000 Nov; Vol. 34 Suppl, pp. S74-85.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Review
اللغة: English
بيانات الدورية: Publisher: Sage Country of Publication: England NLM ID: 0111052 Publication Model: Print Cited Medium: Print ISSN: 0004-8674 (Print) Linking ISSN: 00048674 NLM ISO Abbreviation: Aust N Z J Psychiatry Subsets: MEDLINE
أسماء مطبوعة: Publication: 2012- : London : Sage
Original Publication: [Carlton South, Vic., Australia] : Blackwell Science
مواضيع طبية MeSH: Neuropsychological Tests* , Phenotype*, Genetic Markers/*genetics , Schizophrenia/*genetics, Adult ; Attention ; Child ; Genetic Testing ; Humans ; Risk Factors ; Schizophrenia/diagnosis ; Schizophrenic Psychology
مستخلص: Objective: To review the literature on neurocognitive measures as risk markers for schizophrenia and to present data from the Perth family study of schizophrenia. Of all the risk markers that have been identified, the most promising are deficits in sustained attention.
Method: Inclusion in the review was determined by whether the research addressed a number of key questions: methods of assessing sustained attention; evidence of sustained attention deficits in patients and first-degree relatives including children; the importance of attentional dysfunction in the schizophrenic process and functional outcome; and the biological basis of sustained attention deficits.
Results: Sustained attention deficits are evident in both patients and a proportion of their first-degree relatives, a finding replicated in preliminary data from the Perth family study. The literature suggests that the attention deficit is a stable enduring trait that is independent of clinical state. The neural basis of the deficit may be a functional disconnection between prefrontal and parietal cortex. Attention impairment is an important predictor of functional outcome in patients and the development of social dysfunction in adulthood in the at-risk offspring of patients. However, sustained attention deficits that are measured in childhood results in an unacceptable high false-positive rate (21%) when predicting which at-risk offspring of parents with schizophrenia will develop a schizophrenia spectrum disorder, although the overall classification accuracy (78%) is impressive.
Conclusions: The main findings are that sustained attention deficits are important risk markers for schizophrenia but need to be supplemented by other neurocognitive risk markers to improve predictive accuracy.
Number of References: 80
المشرفين على المادة: 0 (Genetic Markers)
تواريخ الأحداث: Date Created: 20001229 Date Completed: 20010315 Latest Revision: 20170214
رمز التحديث: 20221213
DOI: 10.1080/000486700226
PMID: 11129319
قاعدة البيانات: MEDLINE
الوصف
تدمد:0004-8674
DOI:10.1080/000486700226