التفاصيل البيبلوغرافية
| العنوان: |
The effects of noradrenergic activation of the nucleus tractus solitarius on memory and in potentiating norepinephrine release in the amygdala. |
| المؤلفون: |
Williams CL; Department of Psychology, University of Virginia, Charlottesville 22904, USA. clw3b@virginia.edu, Men D, Clayton EC |
| المصدر: |
Behavioral neuroscience [Behav Neurosci] 2000 Dec; Vol. 114 (6), pp. 1131-44. |
| نوع المنشور: |
Journal Article; Research Support, U.S. Gov't, P.H.S. |
| اللغة: |
English |
| بيانات الدورية: |
Publisher: American Psychological Association Country of Publication: United States NLM ID: 8302411 Publication Model: Print Cited Medium: Print ISSN: 0735-7044 (Print) Linking ISSN: 07357044 NLM ISO Abbreviation: Behav Neurosci Subsets: MEDLINE |
| أسماء مطبوعة: |
Original Publication: Washington, D.C. : American Psychological Association, [c1983- |
| مواضيع طبية MeSH: |
Amygdala/*physiology , Mental Recall/*physiology , Norepinephrine/*physiology , Solitary Nucleus/*physiology, Animals ; Association Learning/physiology ; Brain Mapping ; Conditioning, Classical/physiology ; Discrimination Learning/physiology ; Male ; Maze Learning/physiology ; Neural Pathways/physiology ; Rats ; Rats, Sprague-Dawley ; Retention, Psychology/physiology |
| مستخلص: |
Although it is known that norepinephrine (NE) modulates memory by acting on limbic areas, few studies describe how structures supplying NE to the limbic system, such as the nucleus tractus solitarius (NTS) contribute to this process. The present study examined the effects on memory of activating the NE pathway between the NTS and the amygdala (AMYG). Rats received buffer or the beta-noradrenergic agonist clenbuterol (CLN; 10, 50, or 100 ng/0.5 microl) into the NTS after footshock training in a Y-maze discrimination task. Infusion of 100 ng CLN significantly improved memory when retention was tested in the absence or presence of cues associated with the footshock. Experiment 2 used in vivo microdialysis to determine whether the mnemonic effects of CLN are mediated by influencing NE output in the AMYG. Subjects were given an intra-NTS infusion of CLN or phosphate buffered saline, footshock (0.8 mA, 1 s), and injected with epinephrine (EPI; 0.3 mg/kg ip) or saline. CLN or EPI injection produced a significant increase in NE sampled from the AMYG. These findings indicate that activation of NTS neurons that project to and release NE in the AMYG modulates memory storage processing. |
| معلومات مُعتمدة: |
MHO14505-01 United States MH NIMH NIH HHS |
| المشرفين على المادة: |
X4W3ENH1CV (Norepinephrine) |
| تواريخ الأحداث: |
Date Created: 20010106 Date Completed: 20010315 Latest Revision: 20191210 |
| رمز التحديث: |
20240627 |
| DOI: |
10.1037//0735-7044.114.6.1131 |
| PMID: |
11142645 |
| قاعدة البيانات: |
MEDLINE |
