دورية أكاديمية
Verapamil versus amlodipine in proteinuric non-diabetic nephropathies treated with trandolapril (VVANNTT study): design of a prospective randomized multicenter trial.
| العنوان: | Verapamil versus amlodipine in proteinuric non-diabetic nephropathies treated with trandolapril (VVANNTT study): design of a prospective randomized multicenter trial. |
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| المؤلفون: | Boero R; Division of Nephrology and Dialysis, San Giovanni Bosco Hospital, Turin, Italy. dialtoiv@tin.it, Rollino C, Massara C, Vagelli G, Gonella M, Berto IM, Bajardi P, Perosa P, Malcangi U, Giorgi MP, Ghezzi PM, Borzumati M, Baroni AM, Cogno C, Triolo G, Angelini D, Antonelli A, Quarello F |
| المصدر: | Journal of nephrology [J Nephrol] 2001 Jan-Feb; Vol. 14 (1), pp. 15-8. |
| نوع المنشور: | Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Country of Publication: Italy NLM ID: 9012268 Publication Model: Print Cited Medium: Print ISSN: 1121-8428 (Print) Linking ISSN: 11218428 NLM ISO Abbreviation: J Nephrol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2014- : Heidelberg : Springer Original Publication: Rome : Acta Medica, |
| مواضيع طبية MeSH: | Amlodipine/*therapeutic use , Angiotensin-Converting Enzyme Inhibitors/*therapeutic use , Calcium Channel Blockers/*therapeutic use , Indoles/*therapeutic use , Kidney Diseases/*drug therapy , Proteinuria/*drug therapy , Verapamil/*therapeutic use, Adult ; Aged ; Double-Blind Method ; Drug Therapy, Combination ; Humans ; Middle Aged ; Prospective Studies ; Research Design |
| مستخلص: | Angiotensin converting enzyme inhibitors (ACEI) are the most effective antiproteinuric agents and should be used as first-line drugs in both diabetic and non-diabetic proteinuric nephropathies. The role of calcium channel blockers (CCB) is much more controversial. In diabetic patients verapamil and diltiazem seem more effective than dihydropyridines in reducing urinary protein excretion, and have additive effects with ACEI, but little is available on chronic treatment of non-diabetic nephropathies for non-dihydropyridine CCBs. To test whether the combination of verapamil 180 mg or amlodipine 5 mg with trandolapril 2 mg reduces urinary protein excretion more than trandolapril 2 mg alone, we planned a prospective, randomized, double-blind, multicenter trial. The secondary aims are to evaluate the effects of both treatments on the selectivity of proteinuria and check their safety. Consecutive patients aged between 18 and 70 years with non-diabetic proteinuria > or =2 g/24 h and plasma creatinine < 3 mg/dl or creatinine clearance > or = 20 ml/min are asked to participate. After a four-week run-in during which previous antihypertensive therapy is withdrawn, a single dose of trandolapril 2 mg is given once a day in open conditions for four weeks. At the end of this period patients are randomly assigned to receive once a day, in a double blind fashion, either trandolapril 2 mg and verapamil 180 mg [plus a placebo], or trandolapril 2 mg plus amlodipine 5 mg. They are monitored after one, two, five and eight months. |
| المشرفين على المادة: | 0 (Angiotensin-Converting Enzyme Inhibitors) 0 (Calcium Channel Blockers) 0 (Indoles) 1J444QC288 (Amlodipine) 1T0N3G9CRC (trandolapril) CJ0O37KU29 (Verapamil) |
| تواريخ الأحداث: | Date Created: 20010403 Date Completed: 20010614 Latest Revision: 20141120 |
| رمز التحديث: | 20221213 |
| PMID: | 11281338 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1121-8428 |
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