دورية أكاديمية
Gonadotroph cell pituitary adenomas in males.
| العنوان: | Gonadotroph cell pituitary adenomas in males. |
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| المؤلفون: | Manieri C; UODU Endocrinologia, Dipartimento di Medicina Interna, Università degli Studi di Torino, Torino, Italy., Di Bisceglie C, Razzore P, Fornengo R, Papotti M, Isolato G, Ciccarelli E |
| المصدر: | Panminerva medica [Panminerva Med] 2000 Dec; Vol. 42 (4), pp. 237-40. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Panminerva Medica Country of Publication: Italy NLM ID: 0421110 Publication Model: Print Cited Medium: Print ISSN: 0031-0808 (Print) Linking ISSN: 00310808 NLM ISO Abbreviation: Panminerva Med Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Turin : Panminerva Medica |
| مواضيع طبية MeSH: | Adenoma/*therapy , Pituitary Neoplasms/*therapy, Adenoma/diagnosis ; Adenoma/metabolism ; Adult ; Aged ; Follow-Up Studies ; Humans ; Immunohistochemistry ; Male ; Middle Aged ; Pituitary Neoplasms/diagnosis ; Pituitary Neoplasms/metabolism ; Retrospective Studies |
| مستخلص: | Background: Considered exceptional in the past, gonadotroph cell pituitary adenomas account for 3.5-6.4% of total surgically excised pituitary adenomas when examined with immunospecific staining. The aim of this study was to describe the clinical, hormonal, radiological and immunohistochemical features, the management and the follow-up of our patients with gonadotroph adenoma. Methods: In this retrospective study we describe 14 male subjects aged 19-70 yrs affected by gonadotroph cell pituitary adenomas; the patients were studied by hormonal, radiological and immunohistochemical investigations and followed up for 3-13 yrs by ambulatory and/or hospitalized care. Results: Visual impairment and/or decreased libido and erectile dysfunction were the symptoms at presentation. Increased serum gonadotropin concentrations were shown in 3 patients. Reduced levels of testosterone were present in 9 patients, and normal in the remainder. At diagnosis all patients had pituitary macroadenomas, with wide extrasellar extension in 12. All patients underwent trans-sphenoidal surgery and immunohistochemical staining of surgically excised specimens showed the presence of gonadotroph and alpha-subunit cells in all pituitary adenomas. After surgery 3 patients had clear radiological evidence of normal pituitary; in the others a doubtful MRI picture or a residual adenomatous tissue were present. In the patients who did not undergo radiotherapy immediately after surgery, a regrowth of tumoral tissue was shown in 1-10 yrs. Conclusions: We stress the importance of a close follow-up of patients with gonadotroph adenomas after surgery, and we raise the question of whether radiotherapy may be useful for avoiding any further adenomatous regrowth. |
| تواريخ الأحداث: | Date Created: 20010411 Date Completed: 20010419 Latest Revision: 20041117 |
| رمز التحديث: | 20221213 |
| PMID: | 11294084 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0031-0808 |
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