دورية أكاديمية
Rat mandibular distraction osteogenesis: latency, rate, and rhythm determine the adaptive response.
| العنوان: | Rat mandibular distraction osteogenesis: latency, rate, and rhythm determine the adaptive response. |
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| المؤلفون: | Paccione MF; Laboratory of Developmental Biology and Repair, New York University Medical Center, New York, New York, USA., Mehrara BJ, Warren SM, Greenwald JA, Spector JA, Luchs JS, Longaker MT |
| المصدر: | The Journal of craniofacial surgery [J Craniofac Surg] 2001 Mar; Vol. 12 (2), pp. 175-82. |
| نوع المنشور: | Journal Article; Research Support, U.S. Gov't, P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 9010410 Publication Model: Print Cited Medium: Print ISSN: 1049-2275 (Print) Linking ISSN: 10492275 NLM ISO Abbreviation: J Craniofac Surg |
| أسماء مطبوعة: | Publication: <2014-> : Hagerstown, MD : Lippincott Williams & Wilkins Original Publication: Burlington, Ont. : B.C. Decker, c1990- |
| مواضيع طبية MeSH: | Adaptation, Physiological/*physiology , Mandible/*surgery , Osteogenesis, Distraction/*methods, Animals ; Bone Regeneration/genetics ; Bone Regeneration/physiology ; Bone Remodeling/physiology ; Collagen ; Gene Expression ; Male ; Mandible/blood supply ; Mandible/pathology ; Mandible/physiopathology ; Models, Animal ; Neovascularization, Physiologic/physiology ; Osteogenesis/genetics ; Osteogenesis/physiology ; Osteogenesis, Distraction/classification ; Rats ; Rats, Sprague-Dawley ; Time Factors |
| مستخلص: | Distraction osteogenesis is a well-established technique of endogenous tissue engineering. The biomechanical factors thought to affect the quality of the distraction regenerate include the latency, rate, rhythm, and consolidation period. In an effort to understand the impact of these parameters on regenerate bone formation, this study was designed to decipher the most adaptive response in a rat model of mandibular distraction osteogenesis. Ninety-six adult Sprague-Dawley rats were divided into 16 subgroups (n = 6 per subgroup) based on variations in the distraction parameters (i.e., latency, rate, and rhythm). After a 28-day consolidation period, the mandibles were harvested, decalcified, and sectioned. A standardized histologic ranking system was used to evaluate the effect of each protocol on the adaptive response of the regenerate bone. In this study, we have demonstrated that the latency period dramatically affects the success of distraction osteogenesis. Furthermore, distraction rates up to 0.50 mm per day stimulated excellent regenerate bone formation, whereas greater distraction rates produced a fibrous union. Finally, higher frequency distraction (i.e., increased rhythm) appeared to accelerate regenerate bone formation. We believe that defining the critical parameters of this model will improve future analysis of gene expression during rat mandibular distraction osteogenesis and may facilitate the development of biologically based strategies designed to enhance regenerate bone formation. |
| معلومات مُعتمدة: | R01DE13028-02 United States DE NIDCR NIH HHS |
| المشرفين على المادة: | 9007-34-5 (Collagen) |
| تواريخ الأحداث: | Date Created: 20010421 Date Completed: 20010524 Latest Revision: 20190915 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1097/00001665-200103000-00015 |
| PMID: | 11314629 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1049-2275 |
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| DOI: | 10.1097/00001665-200103000-00015 |