دورية أكاديمية
Lung morphometry after repetitive antenatal glucocorticoid treatment in preterm sheep.
| العنوان: | Lung morphometry after repetitive antenatal glucocorticoid treatment in preterm sheep. |
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| المؤلفون: | Willet KE; Division of Clinical Sciences, Telethon Institute for Child Health Research, Roberts Road, Subiaco, 6008, Australia. karenw@ichr.uwa.edu.au, Jobe AH, Ikegami M, Kovar J, Sly PD |
| المصدر: | American journal of respiratory and critical care medicine [Am J Respir Crit Care Med] 2001 May; Vol. 163 (6), pp. 1437-43. |
| نوع المنشور: | Comparative Study; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Thoracic Society Country of Publication: United States NLM ID: 9421642 Publication Model: Print Cited Medium: Print ISSN: 1073-449X (Print) Linking ISSN: 1073449X NLM ISO Abbreviation: Am J Respir Crit Care Med Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2000- : New York, NY : American Thoracic Society Original Publication: New York, NY : American Lung Association, c1994- |
| مواضيع طبية MeSH: | Disease Models, Animal*, Anti-Inflammatory Agents/*therapeutic use , Betamethasone/*therapeutic use , Fetal Growth Retardation/*pathology , Fetal Growth Retardation/*prevention & control , Fetal Organ Maturity/*drug effects , Glucocorticoids/*therapeutic use , Lung/*anatomy & histology , Lung/*drug effects , Prenatal Care/*methods , Respiratory Distress Syndrome, Newborn/*pathology , Respiratory Distress Syndrome, Newborn/*prevention & control, Analysis of Variance ; Animals ; Animals, Newborn ; Anti-Inflammatory Agents/pharmacology ; Betamethasone/pharmacology ; Dose-Response Relationship, Drug ; Drug Administration Schedule ; Drug Evaluation, Preclinical ; Female ; Fetal Growth Retardation/embryology ; Gestational Age ; Glucocorticoids/pharmacology ; Humans ; Infant, Newborn ; Injections, Intramuscular ; Lung Compliance/drug effects ; Pregnancy ; Pulmonary Alveoli/anatomy & histology ; Pulmonary Alveoli/drug effects ; Random Allocation ; Respiratory Distress Syndrome, Newborn/embryology ; Sheep |
| مستخلص: | Antenatal glucocorticoids are thought to be less effective when delivery occurs more than 7 d after initiation of treatment; therefore, repeat courses are often administered. We examined lung structure after single or repetitive antenatal glucocorticoid injections in fetal sheep. Pregnant ewes received single or repetitive doses of 0.5 mg/kg betamethasone at 7-d intervals by maternal or fetal injection, beginning at D104 or D114 with delivery at D125, D135, or D146 gestation (term = 150 d). Changes in lung structure were more pronounced after repetitive versus single injections. Repetitive fetal or maternal injections beginning at D104 (delivery at D125) resulted in comparable structural changes: alveolar volume increased by 50 to 80%, alveolar numerical density decreased by 30 to 40%, and pleural and interlobular septal volumes decreased by as much as 70%. Similar changes were seen in animals delivered at D135 after repetitive maternal injections beginning at D114. There were no structural differences between control and repetitive betamethasone animals when delivery was delayed until D146, indicating that betamethasone induced structural changes were reversible. |
| المشرفين على المادة: | 0 (Anti-Inflammatory Agents) 0 (Glucocorticoids) 9842X06Q6M (Betamethasone) |
| تواريخ الأحداث: | Date Created: 20010524 Date Completed: 20010628 Latest Revision: 20131121 |
| رمز التحديث: | 20240513 |
| DOI: | 10.1164/ajrccm.163.6.2003098 |
| PMID: | 11371415 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1073-449X |
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| DOI: | 10.1164/ajrccm.163.6.2003098 |