دورية أكاديمية
Glycosidase inhibitors of gem-diamine 1-N-iminosugars. structures in media of enzyme assays.
| العنوان: | Glycosidase inhibitors of gem-diamine 1-N-iminosugars. structures in media of enzyme assays. |
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| المؤلفون: | Kondo KI; Institute of Microbial Chemistry, 3-14-23 Kamiosaki, Shinagawa-ku, Tokyo 141-0021, Japan., Adachi H, Shitara E, Kojima F, Nishimura Y |
| المصدر: | Bioorganic & medicinal chemistry [Bioorg Med Chem] 2001 May; Vol. 9 (5), pp. 1091-5. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print Cited Medium: Print ISSN: 0968-0896 (Print) Linking ISSN: 09680896 NLM ISO Abbreviation: Bioorg Med Chem Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Oxford : Elsevier Science Original Publication: Oxford : New York : Pergamon Press, c1993- |
| مواضيع طبية MeSH: | Carbohydrate Metabolism*, Enzyme Inhibitors/*metabolism , Glycoside Hydrolases/*metabolism , Ketones/*metabolism , alpha-L-Fucosidase/*metabolism, Animals ; Carbohydrates/chemistry ; Carbohydrates/pharmacology ; Diamines/chemistry ; Enzyme Inhibitors/pharmacology ; Glycoside Hydrolases/antagonists & inhibitors ; Hydrogen-Ion Concentration ; Imines/chemistry ; Ketones/chemistry ; Ketones/pharmacology ; Structure-Activity Relationship ; Time Factors ; alpha-L-Fucosidase/antagonists & inhibitors |
| مستخلص: | The relationships between structures and inhibitory activities of glycosidase inhibitors of gem-diamine 1-N-iminosugars in media of enzyme assays have been investigated. It has been proved that gem-diamine 1-N-iminosugar smoothly undergoes a structural change to a hydrated ketone or its derivative via a hemiaminal in the media (pH 5.0-6.3), and that the products generated in the media as well as the parent gem-diamine 1-N-iminosugars potently inhibit glycosidases. |
| المشرفين على المادة: | 0 (Carbohydrates) 0 (Diamines) 0 (Enzyme Inhibitors) 0 (Imines) 0 (Ketones) EC 3.2.1.- (Glycoside Hydrolases) EC 3.2.1.51 (alpha-L-Fucosidase) |
| تواريخ الأحداث: | Date Created: 20010530 Date Completed: 20011004 Latest Revision: 20190901 |
| رمز التحديث: | 20240829 |
| DOI: | 10.1016/s0968-0896(00)00330-8 |
| PMID: | 11377167 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0968-0896 |
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| DOI: | 10.1016/s0968-0896(00)00330-8 |