دورية أكاديمية
Insulin, renin-aldosterone system and blood pressure in obese people.
| العنوان: | Insulin, renin-aldosterone system and blood pressure in obese people. |
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| المؤلفون: | Andronico G; Istituto di Clinica Medica e Malattie Cardiovascolari, Università di Palermo, Palermo, Italy. androp@unipa.it, Cottone S, Mangano MT, Ferraro-Mortellaro R, Baiardi G, Grassi N, Ferrara L, Mulé G, Cerasola G |
| المصدر: | International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity [Int J Obes Relat Metab Disord] 2001 Feb; Vol. 25 (2), pp. 239-42. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 9313169 Publication Model: Print Cited Medium: Print NLM ISO Abbreviation: Int J Obes Relat Metab Disord Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2003->: London : Nature Publishing Group Original Publication: Hampshire, UK : Macmillan Press, c1992-c2004. |
| مواضيع طبية MeSH: | Renin-Angiotensin System*, Aldosterone/*blood , Insulin/*blood , Obesity/*blood , Renin/*blood, Adult ; Blood Pressure ; Cross-Sectional Studies ; Female ; Humans ; Hyperinsulinism ; Hypertension/blood ; Hypertension/etiology ; Male ; Middle Aged ; Obesity, Morbid/blood |
| مستخلص: | Objective: To evaluate the relationship between insulin, the renin-aldosterone system and blood pressure in obese subjects. Design and Methods: A cross sectional study of a group of severely obese normotensive subjects who were surgical candidates (n=39; mean BMI: 47.8+/-1.4) and a group of hypertensive patients (n=57; mean BMI: 28.0+/-0.7) twenty-nine of whom had BMI>27. All subjects were studied after 15 days on a balanced diet. Insulin, plasma renin activity and aldosterone were measured. Results: Fasting insulin, plasma renin activity and aldosterone were higher in severely obese normotensive subjects than in hypertensive subjects (respectively 32.3+/-3.0 vs 13.1+/-1.0 mU/l, P=0.0001; 1.34+/-0.22 vs 0.88+/-0.12 ng/ml/h, P=0.04; 137.2+/-16.2 vs 87.9+/-12.1 pg/ml, P=0.015). Insulin was related to BMI and to aldosterone both in normotensive and in hypertensive patients. Conclusion: Hyperinsulinemia itself does not determine hypertension; in some people it could play a vasodilator role in opposition to the renin-aldosterone system. |
| المشرفين على المادة: | 0 (Insulin) 4964P6T9RB (Aldosterone) EC 3.4.23.15 (Renin) |
| تواريخ الأحداث: | Date Created: 20010619 Date Completed: 20011213 Latest Revision: 20140603 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1038/sj.ijo.0801483 |
| PMID: | 11410826 |
| قاعدة البيانات: | MEDLINE |
| DOI: | 10.1038/sj.ijo.0801483 |
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