دورية أكاديمية
Duodenogastric reflux following cholecystectomy in the dog: role of antroduodenal motor function.
| العنوان: | Duodenogastric reflux following cholecystectomy in the dog: role of antroduodenal motor function. |
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| المؤلفون: | Nogi K; Discovery Research Laboratory, Tanabe Seiyaku Co. Ltd, Toda, Saitama, Japan. K-nogi@tanabe.co.jp, Haruma K, Taniguchi H, Yomota E, Okajima M, Hananoki M, Hata J, Kusunoki H, Onoda Y |
| المصدر: | Alimentary pharmacology & therapeutics [Aliment Pharmacol Ther] 2001 Aug; Vol. 15 (8), pp. 1233-8. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 8707234 Publication Model: Print Cited Medium: Print ISSN: 0269-2813 (Print) Linking ISSN: 02692813 NLM ISO Abbreviation: Aliment Pharmacol Ther Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Oxford : Wiley-Blackwell Original Publication: [Oxford, OX] : Blackwell Scientific Publications, [c1987- |
| مواضيع طبية MeSH: | Cholecystectomy/*adverse effects , Duodenogastric Reflux/*etiology, Animals ; Bile Acids and Salts/analysis ; Disease Models, Animal ; Dogs ; Gastric Juice ; Gastrointestinal Agents/pharmacology ; Gastrointestinal Motility ; Infusions, Intravenous ; Pyloric Antrum/physiopathology ; Trimebutine/pharmacology |
| مستخلص: | Background: Duodenogastric reflux has been implicated in the pathogenesis of gastric ulcer and gastritis. Duodenogastric reflux after cholecystectomy is also a possible cause of post-cholecystectomy syndrome. Aim: To investigate the role of antroduodenal motor function in increased duodenogastric reflux following cholecystectomy and the effect of trimebutine maleate (trimebutine) on the duodenogastric reflux in conscious dogs. Methods: Antropyloric and duodenal motility and bile acids content in the gastric juice were measured for 3 h during the inter-digestive state in dogs with or without cholecystectomy. Results: Bile acids content in the gastric juice of cholecystectomized dogs was significantly higher than that of non-cholecystectomized dogs. The frequency of pyloric relaxation during phase II of the migrating motor complex was significantly increased following cholecystectomy. Intravenous infusion of trimebutine inhibited both the increased duodenogastric reflux and the frequency of pyloric relaxation in the cholecystectomized dog. Conclusion: Duodenogastric reflux and frequency of pyloric relaxations were increased in cholecystectomized dogs and trimebutine suppressed both of them. These findings suggest that the increased frequency of pyloric relaxation contributes to the duodenogastric reflux following cholecystectomy. |
| المشرفين على المادة: | 0 (Bile Acids and Salts) 0 (Gastrointestinal Agents) QZ1OJ92E5R (Trimebutine) |
| تواريخ الأحداث: | Date Created: 20010727 Date Completed: 20011219 Latest Revision: 20190901 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1046/j.1365-2036.2001.01035.x |
| PMID: | 11472328 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0269-2813 |
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| DOI: | 10.1046/j.1365-2036.2001.01035.x |