دورية أكاديمية
Fatal adenovirus type 7b infection in a child with Smith-Lemli-Opitz syndrome.
| العنوان: | Fatal adenovirus type 7b infection in a child with Smith-Lemli-Opitz syndrome. |
|---|---|
| المؤلفون: | Beby-Defaux A; Laboratory of Virology, University Hospital Center La Milétrie, Poitiers, France., Maille L, Chabot S, Nassimi A, Oriot D, Agius G |
| المصدر: | Journal of medical virology [J Med Virol] 2001 Sep; Vol. 65 (1), pp. 66-9. |
| نوع المنشور: | Case Reports; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Liss Country of Publication: United States NLM ID: 7705876 Publication Model: Print Cited Medium: Print ISSN: 0146-6615 (Print) Linking ISSN: 01466615 NLM ISO Abbreviation: J Med Virol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: New York Ny : Wiley-Liss Original Publication: New York, Liss. |
| مواضيع طبية MeSH: | Smith-Lemli-Opitz Syndrome*, Adenovirus Infections, Human/*complications , Adenoviruses, Human/*classification , Adenoviruses, Human/*isolation & purification, Adenovirus Infections, Human/diagnosis ; Adenovirus Infections, Human/virology ; Adenoviruses, Human/genetics ; Child, Preschool ; Fatal Outcome ; Female ; Humans ; Nasopharynx/virology |
| مستخلص: | Adenovirus type 7 causes worldwide respiratory tract infections, mainly in children. Severe systemic infections can occur, especially in immunocompromised patients and in patients with underlying chronic diseases. This report describes the first case of a fatal disseminated adenovirus type 7 infection in a child with Smith-Lemli-Opitz syndrome, a rare autosomal recessive disorder due to a primary enzymatic defect in cholesterol metabolism. Nasopharyngeal secretions and autopsy specimens including liver, lung, pleural fluid, and rectum were collected for viral culture. Adenovirus serotype 7 strains were obtained from all anatomic sites, except the liver. All these clinical isolates were analyzed using restriction endonuclease digestion of the genome, identifying them as genome type 7b, a virulent type. In this case, the fatal evolution could have been accelerated by the presence of an immunodeficiency although immunodeficiency is not included in the definition of Smith-Lemli-Opitz syndrome. The frequent recurrent banal infections in Smith-Lemli-Opitz syndrome could be prevented by a cholesterol supplementation regimen. Finally, this report emphasizes the need for efficient therapy for disseminated adenovirus infections, especially for virulent genome types. (Copyright 2001 Wiley-Liss, Inc.) |
| References: | Clin Infect Dis. 1998 Nov;27(5):1194-200. (PMID: 9827268) J Lipid Res. 1995 Jul;36(7):1595-601. (PMID: 7595082) J Pediatr. 1964 Feb;64:210-7. (PMID: 14119520) J Med Virol. 1996 Jul;49(3):170-7. (PMID: 8818961) Am J Clin Pathol. 1971 Jan;55(1):34-9. (PMID: 4322341) Am J Med Genet. 1997 Jan 31;68(3):305-10. (PMID: 9024564) Eur J Pediatr. 1992 Apr;151(4):291-4. (PMID: 1354158) Microbiol Immunol. 1983;27(9):817-22. (PMID: 6316118) Pediatr Infect Dis J. 1995 Nov;14(11):1003-4. (PMID: 8584339) J Clin Microbiol. 1985 Mar;21(3):403-8. (PMID: 3980690) |
| تواريخ الأحداث: | Date Created: 20010816 Date Completed: 20011025 Latest Revision: 20200422 |
| رمز التحديث: | 20240627 |
| مُعرف محوري في PubMed: | PMC7167148 |
| PMID: | 11505445 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0146-6615 |
|---|