دورية أكاديمية
Breast cancer risk in women who have had children with different partners.
| العنوان: | Breast cancer risk in women who have had children with different partners. |
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| المؤلفون: | Lambe M; Department of Medical Epidemiology, Karolinska Institutet, Stockholm, Sweden. Mats.Lambe@mep.ki.se, Rossing MA, Wuu J, Hsieh C |
| المصدر: | International journal of cancer [Int J Cancer] 2001 Sep; Vol. 93 (6), pp. 907-10. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Liss Country of Publication: United States NLM ID: 0042124 Publication Model: Print Cited Medium: Print ISSN: 0020-7136 (Print) Linking ISSN: 00207136 NLM ISO Abbreviation: Int J Cancer Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 1995- : New York, NY : Wiley-Liss Original Publication: 1966-1984 : Genève : International Union Against Cancer |
| مواضيع طبية MeSH: | Sexual Partners*, Breast Neoplasms/*epidemiology , Breast Neoplasms/*immunology, Adult ; Age Factors ; Aged ; Fathers ; Female ; Humans ; Middle Aged ; Multivariate Analysis ; Odds Ratio ; Parity ; Risk |
| مستخلص: | The fetal antigen hypothesis suggests that the lowered risk of breast cancer in parous women may be afforded by the development of antibodies to fetal antigens that are structurally similar to mammary cancer antigens. It has previously been hypothesized that the likelihood of developing such antibodies may be higher among women who have had children with more than 1 partner. Utilizing information on parenthood and breast cancer available in nationwide Swedish registers, we undertook a case-control study nested within a nation-wide cohort to address this issue. Number of partners fathering a child was categorized as 1, 2 and 3 or more. All analyses were restricted to subjects with 2 or more births and encompassed a total of 20,881 women with breast cancer and 111,989 control women. In an unadjusted analysis, the risk of breast cancer was somewhat lower (odds ratio [OR] = 0.94, 95% confidence interval [CI] 0.89-0.99) in women who had had children with 2 different partners compared with women who had had children conceived with the same partner. After adjustment for parity, age at first birth and educational level, however, the risk of breast cancer was slightly elevated (OR = 1.09, 95% CI: 1.03-1.15). Among women who had had children with 3 or more different men, the pattern was similar. The present results provide no support for the hypothesis that greater antigenic exposure afforded by having children with more than 1 man may reduce the risk of breast cancer. It remains possible, however, that pregnancy may influence breast cancer risk through some immunologic mechanism; further testing of the fetal antigen hypothesis may require development of relevant laboratory measures. (Copyright 2001 Wiley-Liss, Inc.) |
| التعليقات: | Comment in: Int J Cancer. 2002 Mar 10;98(2):316-9. (PMID: 11857425) |
| معلومات مُعتمدة: | 5RO1 CA 73703 United States CA NCI NIH HHS |
| تواريخ الأحداث: | Date Created: 20010824 Date Completed: 20010920 Latest Revision: 20190708 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1002/ijc.1414 |
| PMID: | 11519056 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0020-7136 |
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| DOI: | 10.1002/ijc.1414 |