دورية أكاديمية
Two-step process for photoreceptor formation in Drosophila.
| العنوان: | Two-step process for photoreceptor formation in Drosophila. |
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| المؤلفون: | Mollereau B; Department of Biology, New York University, New York, USA., Dominguez M, Webel R, Colley NJ, Keung B, de Celis JF, Desplan C |
| المصدر: | Nature [Nature] 2001 Aug 30; Vol. 412 (6850), pp. 911-3. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print Cited Medium: Print ISSN: 0028-0836 (Print) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Basingstoke : Nature Publishing Group Original Publication: London, Macmillan Journals ltd. |
| مواضيع طبية MeSH: | Homeodomain Proteins/*physiology , Photoreceptor Cells, Invertebrate/*physiology , Transcription Factors/*physiology, Animals ; Cell Differentiation ; Drosophila ; Drosophila Proteins ; Female ; Gene Expression ; Homeodomain Proteins/genetics ; Male ; Morphogenesis ; Photoreceptor Cells, Invertebrate/cytology ; Photoreceptor Cells, Invertebrate/ultrastructure ; Rhodopsin/biosynthesis ; Transcription Factors/genetics ; Zinc Fingers |
| مستخلص: | The formation of photoreceptor cells (PRCs) in Drosophila serves as a paradigm for understanding neuronal determination and differentiation. During larval stages, a precise series of sequential inductive processes leads to the recruitment of eight distinct PRCs (R1-R8). But, final photoreceptor differentiation, including rhabdomere morphogenesis and opsin expression, is completed four days later, during pupal development. It is thought that photoreceptor cell fate is irreversibly established during larval development, when each photoreceptor expresses a particular set of transcriptional regulators and sends its projection to different layers of the optic lobes. Here, we show that the spalt (sal) gene complex encodes two transcription factors that are required late in pupation for photoreceptor differentiation. In the absence of the sal complex, rhabdomere morphology and expression of opsin genes in the inner PRCs R7 and R8 are changed to become identical to those of outer R1-R6 PRCs. However, these cells maintain their normal projections to the medulla part of the optic lobe, and not to the lamina where outer PRCs project. These data indicate that photoreceptor differentiation occurs as a two-step process. First, during larval development, the photoreceptor neurons become committed and send their axonal projections to their targets in the brain. Second, terminal differentiation is executed during pupal development and the photoreceptors adopt their final cellular properties. |
| معلومات مُعتمدة: | R01 EY008768 United States EY NEI NIH HHS |
| المشرفين على المادة: | 0 (Drosophila Proteins) 0 (Homeodomain Proteins) 0 (Transcription Factors) 0 (salm protein, Drosophila) 9009-81-8 (Rhodopsin) |
| تواريخ الأحداث: | Date Created: 20010831 Date Completed: 20010927 Latest Revision: 20191114 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1038/35091076 |
| PMID: | 11528479 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0028-0836 |
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| DOI: | 10.1038/35091076 |