دورية أكاديمية
[Subforms of transcription factor Oct-1 synthesized in lymphocytes].
| العنوان: | [Subforms of transcription factor Oct-1 synthesized in lymphocytes]. |
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| عنوان ترانسليتريتد: | Subformy faktora transkriptsii Oct-1, sinteziruemye v limfotsitakh. |
| المؤلفون: | Pankratova EV, Deev IE, Zhenilo SV, Anfalova TV, Polianovskiĭ OL |
| المصدر: | Molekuliarnaia biologiia [Mol Biol (Mosk)] 2001 Sep-Oct; Vol. 35 (5), pp. 816-23. |
| نوع المنشور: | English Abstract; Journal Article |
| اللغة: | Russian |
| بيانات الدورية: | Publisher: Izdatelstvo Nauka Country of Publication: Russia (Federation) NLM ID: 0105454 Publication Model: Print Cited Medium: Print ISSN: 0026-8984 (Print) Linking ISSN: 00268984 NLM ISO Abbreviation: Mol Biol (Mosk) Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Moskva : Izdatelstvo Nauka |
| مواضيع طبية MeSH: | DNA-Binding Proteins/*biosynthesis , Lymphocytes/*metabolism , Protein Isoforms/*biosynthesis , Transcription Factors/*biosynthesis, Amino Acid Sequence ; Animals ; Base Sequence ; Cells, Cultured ; Cloning, Molecular ; DNA Primers ; DNA, Complementary ; DNA-Binding Proteins/chemistry ; DNA-Binding Proteins/genetics ; Host Cell Factor C1 ; Mice ; Molecular Sequence Data ; Octamer Transcription Factor-1 ; Protein Isoforms/chemistry ; Protein Isoforms/genetics ; RNA, Messenger/genetics ; Sequence Homology, Amino Acid ; Transcription Factors/chemistry ; Transcription Factors/genetics |
| مستخلص: | Transcription factor Oct-1 is ubiquitous, participating in expression of the cell housekeeping genes as well as in differentiation of lymphocytes and activation of transcription of immunoglobulin genes in B cells. A new tissue-specific form of Oct-1 (Oct-1L) was found in lymphoid cells of bone marrow, lymph nodes, spleen, thymus, as well as in the cell lines of B and T lymphocytes at different stages of differentiation. This isoform was not found in embryonal and nonlymphoid tissues and cell lines. The complete structure of the oct-1L mRNA was determined, which generally corresponds to the structure of mouse Oct-1b. The difference between oct-1L and isoforms oct-a, b, and c functioning in all cells is replacement of the long first 5'-terminal exon (the 1U exon) encoding 21 amino acid residues with a short one encoding 10 amino acids in the isoforms Oct-1L and Oct-1R. Interestingly, attempts to find mature oct-1 mRNA simultaneously containing the 1L and 1U exons were unsuccessful. The parallel synthesis of "ubiquitous" isoforms Oct-1a, b, and c as well as tissue-specific Oct-1L and Oct-1R in lymphocytes and their precursors may be due either to a high demand of these cells for Oct-1 or to selective participation of different Oct-1 isoforms in regulation of the housekeeping genes and genes involved in the B and T cell differentiation and synthesis of imminoglobulins. |
| المشرفين على المادة: | 0 (DNA Primers) 0 (DNA, Complementary) 0 (DNA-Binding Proteins) 0 (Hcfc1 protein, mouse) 0 (Host Cell Factor C1) 0 (Octamer Transcription Factor-1) 0 (Pou2f1 protein, mouse) 0 (Protein Isoforms) 0 (RNA, Messenger) 0 (Transcription Factors) |
| تواريخ الأحداث: | Date Created: 20011019 Date Completed: 20011213 Latest Revision: 20061115 |
| رمز التحديث: | 20231215 |
| PMID: | 11605534 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0026-8984 |
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