دورية أكاديمية
Molecular markers for failure of sulfadoxine-pyrimethamine and chlorproguanil-dapsone treatment of Plasmodium falciparum malaria.
| العنوان: | Molecular markers for failure of sulfadoxine-pyrimethamine and chlorproguanil-dapsone treatment of Plasmodium falciparum malaria. |
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| المؤلفون: | Kublin JG; Malaria Section, Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD, USA. jkublin@medicine.umaryland.edu, Dzinjalamala FK, Kamwendo DD, Malkin EM, Cortese JF, Martino LM, Mukadam RA, Rogerson SJ, Lescano AG, Molyneux ME, Winstanley PA, Chimpeni P, Taylor TE, Plowe CV |
| المصدر: | The Journal of infectious diseases [J Infect Dis] 2002 Feb 01; Vol. 185 (3), pp. 380-8. Date of Electronic Publication: 2002 Jan 17. |
| نوع المنشور: | Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: United States NLM ID: 0413675 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0022-1899 (Print) Linking ISSN: 00221899 NLM ISO Abbreviation: J Infect Dis Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Jan. 2011- : Oxford : Oxford University Press Original Publication: 1904-2010 : Chicago, IL : University of Chicago Press |
| مواضيع طبية MeSH: | Mutation*, Antimalarials/*therapeutic use , Dapsone/*administration & dosage , Dihydropteroate Synthase/*genetics , Malaria, Falciparum/*drug therapy , Proguanil/*administration & dosage , Pyrimethamine/*therapeutic use , Sulfadoxine/*therapeutic use , Tetrahydrofolate Dehydrogenase/*genetics, Biomarkers ; Child ; Child, Preschool ; Double-Blind Method ; Drug Combinations ; Drug Resistance, Bacterial ; Humans ; Infant ; Proguanil/analogs & derivatives ; Prospective Studies ; Sensitivity and Specificity ; Treatment Failure |
| مستخلص: | Molecular assays for monitoring sulfadoxine-pyrimethamine-resistant Plasmodium falciparum have not been implemented because of the genetic and statistical complexity of the parasite mutations that confer resistance and their relation to treatment outcomes. This study analyzed pretreatment dihydrofolate reductase (DHFR) and dihydropteroate synthase (DHPS) genotypes and treatment outcomes in a double-blind, placebo-controlled trial of sulfadoxine-pyrimethamine and chlorproguanil-dapsone treatment for uncomplicated P. falciparum malaria. Multiple logistic regression was used to identify mutations that were predictive of treatment failure and to identify interactions and confounding factors. Infections caused by parasites with 3 DHFR mutations and 2 DHPS mutations (the "quintuple mutant") were associated with sulfadoxine-pyrimethamine treatment failure but not with chlorproguanil-dapsone treatment failure. The presence of a single DHFR mutation (Arg-59) with a single DHPS mutation (Glu-540) accurately predicted the presence of the quintuple mutant. If this model is validated in other populations, it will finally be possible to use molecular markers for surveillance of antifolate-resistant P. falciparum malaria in Africa. |
| معلومات مُعتمدة: | AI-40539 United States AI NIAID NIH HHS; AI-44824 United States AI NIAID NIH HHS |
| المشرفين على المادة: | 0 (Antimalarials) 0 (Biomarkers) 0 (Drug Combinations) 37338-39-9 (fanasil, pyrimethamine drug combination) 88463U4SM5 (Sulfadoxine) 8O3249M729 (chlorproguanil) 8W5C518302 (Dapsone) EC 1.5.1.3 (Tetrahydrofolate Dehydrogenase) EC 2.5.1.15 (Dihydropteroate Synthase) S61K3P7B2V (Proguanil) Z3614QOX8W (Pyrimethamine) |
| تواريخ الأحداث: | Date Created: 20020125 Date Completed: 20020221 Latest Revision: 20220321 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1086/338566 |
| PMID: | 11807721 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0022-1899 |
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| DOI: | 10.1086/338566 |