دورية أكاديمية
alpha(1)-Adrenoceptor agonists: the identification of novel alpha(1A )subtype selective 2'-heteroaryl-2-(phenoxymethyl)imidazolines.
| العنوان: | alpha(1)-Adrenoceptor agonists: the identification of novel alpha(1A )subtype selective 2'-heteroaryl-2-(phenoxymethyl)imidazolines. |
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| المؤلفون: | Bishop MJ; GlaxoSmithKline Research and Development, 5 Moore Drive, Research Triangle Park, NC 27709, USA.mjb45288@glaxowellcome.com, Barvian KA, Berman J, Bigham EC, Garrison DT, Gobel MJ, Hodson SJ, Irving PE, Liacos JA, Navas F 3rd, Saussy DL, Speake JD |
| المصدر: | Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2002 Feb 11; Vol. 12 (3), pp. 471-5. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print Cited Medium: Print ISSN: 0960-894X (Print) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Oxford : Elsevier Science Ltd Original Publication: Oxford ; New York : Pergamon Press, c1991- |
| مواضيع طبية MeSH: | Adrenergic alpha-1 Receptor Agonists*, Adrenergic alpha-Agonists/*pharmacology , Imidazoles/*chemical synthesis , Imidazoles/*pharmacology , Phenyl Ethers/*chemical synthesis , Phenyl Ethers/*pharmacology, Humans ; Hydrogen Bonding ; Receptors, Adrenergic, alpha-1 ; Recombinant Proteins ; Structure-Activity Relationship ; Urinary Incontinence, Stress/prevention & control |
| مستخلص: | Novel 2'-heteroaryl-2-(phenoxymethyl)imidazolines have been identified as potent agonists of the cloned human alpha(1)-adrenoceptors in vitro. The nature of the 2'-heteroaryl group can have significant effects on the potency, efficacy, and subtype selectivity in this series. alpha(1A) Subtype selective agonists have been identified. |
| المشرفين على المادة: | 0 (ADRA1A protein, human) 0 (Adrenergic alpha-1 Receptor Agonists) 0 (Adrenergic alpha-Agonists) 0 (Imidazoles) 0 (Phenyl Ethers) 0 (Receptors, Adrenergic, alpha-1) 0 (Recombinant Proteins) |
| تواريخ الأحداث: | Date Created: 20020130 Date Completed: 20020618 Latest Revision: 20190819 |
| رمز التحديث: | 20240627 |
| DOI: | 10.1016/s0960-894x(01)00764-8 |
| PMID: | 11814822 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0960-894X |
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| DOI: | 10.1016/s0960-894x(01)00764-8 |