دورية أكاديمية
Trastuzumab: designer drug or fashionable fad?
| العنوان: | Trastuzumab: designer drug or fashionable fad? |
|---|---|
| المؤلفون: | Freebairn AJ; Wessex Cancer Centre, Southampton General Hospital, UK., Last AJ, Illidg TM |
| المصدر: | Clinical oncology (Royal College of Radiologists (Great Britain)) [Clin Oncol (R Coll Radiol)] 2001; Vol. 13 (6), pp. 427-33. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: W.B. Saunders Country of Publication: England NLM ID: 9002902 Publication Model: Print Cited Medium: Print ISSN: 0936-6555 (Print) Linking ISSN: 09366555 NLM ISO Abbreviation: Clin Oncol (R Coll Radiol) Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2003- : London : W.B. Saunders Original Publication: [London, UK] : Springer International, [c1989- |
| مواضيع طبية MeSH: | Antibodies, Monoclonal/*therapeutic use , Antineoplastic Agents/*therapeutic use , Breast Neoplasms/*drug therapy, Animals ; Antibodies, Monoclonal, Humanized ; Clinical Trials as Topic ; Genes, erbB-2/genetics ; Humans ; Receptor, ErbB-2/immunology ; Trastuzumab |
| مستخلص: | Trastuzumab (Herceptin) is the first monoclonal antibody to be approved for the treatment of a solid tumour and is directed against the c-erb-B2 receptor. c-erb-B2 is a member of the epidermal growth factor family and approximately 25% of breast cancers express such receptors, which appear to confer a poorer prognosis and may be an indicator of resistance to cytotoxic chemotherapy. This review assesses the mechanisms of action of trastuzumab, discusses the measurement of the HER-2/neu gene and its products, and describes the preclinical and clinical studies that have been instrumental to date in the emergence of trastuzumab in clinical practice. |
| Number of References: | 49 |
| المشرفين على المادة: | 0 (Antibodies, Monoclonal) 0 (Antibodies, Monoclonal, Humanized) 0 (Antineoplastic Agents) EC 2.7.10.1 (Receptor, ErbB-2) P188ANX8CK (Trastuzumab) |
| تواريخ الأحداث: | Date Created: 20020205 Date Completed: 20020712 Latest Revision: 20190916 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1053/clon.2001.9306 |
| PMID: | 11824879 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0936-6555 |
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| DOI: | 10.1053/clon.2001.9306 |