دورية أكاديمية
Psammaplin A, a chitinase inhibitor isolated from the Fijian marine sponge Aplysinella rhax.
| العنوان: | Psammaplin A, a chitinase inhibitor isolated from the Fijian marine sponge Aplysinella rhax. |
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| المؤلفون: | Tabudravu JN; Marine Natural Products Laboratory, Department of Chemistry, University of Aberdeen, Old Aberdeen AB24 3UE, Scotland, UK., Eijsink VG, Gooday GW, Jaspars M, Komander D, Legg M, Synstad B, van Aalten DM |
| المصدر: | Bioorganic & medicinal chemistry [Bioorg Med Chem] 2002 Apr; Vol. 10 (4), pp. 1123-8. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print Cited Medium: Print ISSN: 0968-0896 (Print) Linking ISSN: 09680896 NLM ISO Abbreviation: Bioorg Med Chem Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Oxford : Elsevier Science Original Publication: Oxford : New York : Pergamon Press, c1993- |
| مواضيع طبية MeSH: | Chitinases/*antagonists & inhibitors , Disulfides/*isolation & purification , Porifera/*chemistry , Tyrosine/*analogs & derivatives , Tyrosine/*isolation & purification, Animals ; Antifungal Agents/chemistry ; Antifungal Agents/isolation & purification ; Catalytic Domain ; Disulfides/chemistry ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/isolation & purification ; Insecta/drug effects ; Insecticides/chemistry ; Insecticides/isolation & purification ; Kinetics ; Molecular Structure ; Plant Proteins/antagonists & inhibitors ; Spores, Fungal/drug effects ; Tyrosine/chemistry |
| مستخلص: | Several brominated tyrosine derived compounds, psammaplins A (1), K (2) and L (3) as well as bisaprasin (4) were isolated from the Fijian marine sponge Aplysinella rhax during a bioassay guided isolation protocol. Their structures were determined using NMR and MS techniques. Psammaplin A was found to moderately inhibit chitinase B from Serratia marcescens, the mode of inhibition being non-competitive. Crystallographic studies suggest that a disordered psammaplin A molecule is bound near the active site. Interestingly, psammaplin A was found to be a potent antifungal agent. |
| سلسلة جزيئية: | PDB 1GPF |
| المشرفين على المادة: | 0 (Antifungal Agents) 0 (Disulfides) 0 (Enzyme Inhibitors) 0 (Insecticides) 0 (Plant Proteins) 110659-91-1 (psammaplin A) 42HK56048U (Tyrosine) EC 3.2.1.14 (Chitinases) EC 3.2.1.14 (PLC-B protein, Phytolacca americana) |
| تواريخ الأحداث: | Date Created: 20020212 Date Completed: 20020911 Latest Revision: 20190901 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/s0968-0896(01)00372-8 |
| PMID: | 11836123 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0968-0896 |
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| DOI: | 10.1016/s0968-0896(01)00372-8 |