دورية أكاديمية
IL-12 induces monocyte IL-18 binding protein expression via IFN-gamma.
| العنوان: | IL-12 induces monocyte IL-18 binding protein expression via IFN-gamma. |
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| المؤلفون: | Veenstra KG; Department of Medicine, Division of Hematology/Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA., Jonak ZL, Trulli S, Gollob JA |
| المصدر: | Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2002 Mar 01; Vol. 168 (5), pp. 2282-7. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Association of Immunologists Country of Publication: United States NLM ID: 2985117R Publication Model: Print Cited Medium: Print ISSN: 0022-1767 (Print) Linking ISSN: 00221767 NLM ISO Abbreviation: J Immunol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Bethesda, MD : American Association of Immunologists Original Publication: Baltimore : Williams & Wilkins, c1950- |
| مواضيع طبية MeSH: | Transcriptional Activation*, Glycoproteins/*biosynthesis , Interferon-gamma/*physiology , Interleukin-12/*pharmacology , Monocytes/*immunology, Antibodies/pharmacology ; Cells, Cultured ; Cytokines/pharmacology ; Glycoproteins/genetics ; Humans ; Intercellular Signaling Peptides and Proteins ; Interferon-gamma/antagonists & inhibitors ; Interferon-gamma/immunology ; Interleukin-12/therapeutic use ; Killer Cells, Natural/immunology ; Kinetics ; Monocytes/drug effects ; Neoplasms/drug therapy ; Neoplasms/immunology ; RNA, Messenger/biosynthesis ; Th1 Cells/immunology |
| مستخلص: | IL-18 is a Th1 cytokine that synergizes with IL-12 and IL-2 in the stimulation of lymphocyte IFN-gamma production. IL-18 binding protein (IL-18BP) is a recently discovered inhibitor of IL-18 that is distinct from the IL-1 and IL-18 receptor families. In this report we show that IL-18BPa, the IL-18BP isoform with the highest affinity for IL-18, was strongly induced by IL-12 in human PBMC. Other Th1 cytokines, including IFN-gamma, IL-2, IL-15, and IL-18, were also capable of augmenting IL-18BPa expression. In contrast, IL-1alpha, IL-1beta, TNF-alpha, IFN-gamma-inducible protein-10, and Th2 cytokines such as IL-4 and IL-10 did not induce IL-18BPa. Although monocytes were found to be the primary source of IL-18BPa, the induction of IL-18BPa by IL-12 was mediated through IFN-gamma derived predominantly from NK cells. IL-18BPa production was observed in cancer patients receiving recombinant human IL-12 and correlated with the magnitude of IFN-gamma production. The IFN-gamma/IL-18BPa negative feedback loop identified in this study may be capable of broadly controlling immune activation by cytokines that synergize with IL-18 to induce IFN-gamma and probably plays a key role in the modulation of both innate and adaptive immunity. |
| معلومات مُعتمدة: | K23 RR 15541-02 United States RR NCRR NIH HHS |
| المشرفين على المادة: | 0 (Antibodies) 0 (Cytokines) 0 (Glycoproteins) 0 (Intercellular Signaling Peptides and Proteins) 0 (RNA, Messenger) 0 (interleukin-18 binding protein) 187348-17-0 (Interleukin-12) 82115-62-6 (Interferon-gamma) |
| تواريخ الأحداث: | Date Created: 20020223 Date Completed: 20020315 Latest Revision: 20190515 |
| رمز التحديث: | 20231215 |
| DOI: | 10.4049/jimmunol.168.5.2282 |
| PMID: | 11859116 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0022-1767 |
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| DOI: | 10.4049/jimmunol.168.5.2282 |