دورية أكاديمية
Coronary hemodynamics during reperfusion following acute coronary ligation in dogs.
| العنوان: | Coronary hemodynamics during reperfusion following acute coronary ligation in dogs. |
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| المؤلفون: | Parker PE, Bashour FA, Downey HF, Kechejian SJ, Williams AG |
| المصدر: | American heart journal [Am Heart J] 1975 Nov; Vol. 90 (5), pp. 593-9. |
| نوع المنشور: | Journal Article; Research Support, U.S. Gov't, P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: Mosby Country of Publication: United States NLM ID: 0370465 Publication Model: Print Cited Medium: Print ISSN: 0002-8703 (Print) Linking ISSN: 00028703 NLM ISO Abbreviation: Am Heart J Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: St. Louis, MO : Mosby |
| مواضيع طبية MeSH: | Coronary Circulation* , Vascular Resistance*, Myocardial Infarction/*physiopathology, Animals ; Blood Flow Velocity ; Cesium Radioisotopes ; Dogs ; Female ; Male ; Myocardial Infarction/therapy ; Perfusion ; Radioisotopes ; Scandium ; Strontium Radioisotopes ; Time Factors |
| مستخلص: | The coronary hemodynamic effects of re-establishing blood flow to ischemic myocardium and the regional distribution of myocardial flow during reperfusion were studied in anesthetized open-chest dogs. A large portion of the left ventricular wall was rendered ischemic by occlusion of the left anterior descending coronary artery for 2 hours. During reperfusion of the LAD, coronary resistance in the reperfused vasculature increased progressively for the first 3 hours, while resistance in the intact LC vasculature was unchanged. Minimal resistances in the reperfused vascular bed, calculated from mean aortic pressure and peak coronary reactive hyperemic blood flow following a 90 sec. LAD occlusion, were elevated significantly during reperfusion. The increased minimal resistance values, which reflect the passive physical component of resistance, indicate structural changes in the reperfused vascular bed which were evident shortly after the initiation of reperfusion and persisted throughout the experimental period. Coronary resistances (RH) in the reperfused (LAD) and intact (LC) vasculatures during the reactive hyperemia following 10 sec. coronary occlusions were evaluated. During reperfusion, RH in the reperfused vasculature increased progressively while RH in the intact bed was unchanged. The marked increase in RH in the LAD indicates that the reactive hyperemic flow response to a consistent period of coronary occlusion progressively diminished, and reflects a gradual reduction in the vasodilatory potential of the reperfused coronary circulation. The regional distribution of myocardial blood flow following 5 minutes, 2 hours, and 4 hours of reperfusion was measured with multiple injections of radioactive microspheres. These measurements demonstrated a progressive reduction of blood flow to the reperfused myocardium with no significant change in flow to the control myocardium. In contrast to the uniform transmural distribution of flow in the normal myocardium, the reperfused region showed a distinctly nonuniform distribution of flow after 2 hours and 4 hours of reperfusion, with more severe reduction of flow to the endocardial layer. These studies would suggest that rechannelling blood flow distal to an acute coronary occlusion in human subjects might not in itself be capable of reversing the myocardial injury. It is hoped that additional therapeutic measures might be applied to salvage the injured myocardium. |
| المشرفين على المادة: | 0 (Cesium Radioisotopes) 0 (Radioisotopes) 0 (Strontium Radioisotopes) YUJ4U1EW7R (Scandium) |
| تواريخ الأحداث: | Date Created: 19751101 Date Completed: 19760114 Latest Revision: 20190626 |
| رمز التحديث: | 20221208 |
| DOI: | 10.1016/0002-8703(75)90223-9 |
| PMID: | 1190037 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0002-8703 |
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| DOI: | 10.1016/0002-8703(75)90223-9 |