دورية أكاديمية
[A case of rheumatoid arthritis complicated with a pneumonitis during concomitant treatment with methotrexate and bucillamine].
| العنوان: | [A case of rheumatoid arthritis complicated with a pneumonitis during concomitant treatment with methotrexate and bucillamine]. |
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| المؤلفون: | Miwa Y; Division of Rheumatology and Clinical Immunology, Showa University School of Medicine, Shinagawa-ku, Tokyo., Kaga S, Hanaoka R, Shiozawa F, Hanyuda M, Kasama T, Negishi M, Ide H |
| المصدر: | Ryumachi. [Rheumatism] [Ryumachi] 2002 Feb; Vol. 42 (1), pp. 70-5. |
| نوع المنشور: | Case Reports; English Abstract; Journal Article |
| اللغة: | Japanese |
| بيانات الدورية: | Publisher: Nippon Ryūmachi Gakkai Country of Publication: Japan NLM ID: 0153217 Publication Model: Print Cited Medium: Print ISSN: 0300-9157 (Print) Linking ISSN: 03009157 NLM ISO Abbreviation: Ryumachi Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Tōkyō, Nippon Ryūmachi Gakkai [1958?]- |
| مواضيع طبية MeSH: | Anti-Inflammatory Agents, Non-Steroidal/*adverse effects , Antirheumatic Agents/*adverse effects , Arthritis, Rheumatoid/*drug therapy , Cysteine/*adverse effects , Methotrexate/*adverse effects , Pneumonia/*chemically induced, Aged ; Cysteine/analogs & derivatives ; Female ; Humans |
| مستخلص: | A 70-year-old female was diagnosed as having rheumatoid arthritis (RA) in 1971, which was then treated with steroid and nonsteroidal anti-inflammatory drugs. In 1999, after total replacement of her knee joint, 4 mg of methotrexate (MTX) per week was administered. Two months after the MTX administration, 200 mg of bucillamine per day was administered. On May 10, 2001, the patient was rushed to the hospital due to fever and difficulty in breathing. Chest X-ray and computed tomography (CT) revealed shadows of ground-glass-like opacity occurring sporadically in many places in the upper lung field bilaterally and interstitial shadows mainly on the lateral side of the lower lung field bilaterally. Instead of MTX and bucillamine, which were withheld, an MTX antagonist was administered and oxygen-supported therapy was performed; consequently, the patient recovered without the need to increase the amount of steroid. The percentage of lymphocytes in the broncholaveolar lavage fluid increased to 72%, and the CD4/CD8 ratio to 3.13. The level of serum KL-6 increased while that of serum SP-D returned to the normal level at different time. Following MTX and bucillamine administration, shadows of ground-glass-like opacity occurred sporadically in many places in the upper lung field bilaterally, which is not usually observed. It is suggested that such an unusual pulmonary disorder occurred due to concomitant use of drugs or other factors. |
| المشرفين على المادة: | 0 (Anti-Inflammatory Agents, Non-Steroidal) 0 (Antirheumatic Agents) K848JZ4886 (Cysteine) R80LRA5WTF (bucillamine) YL5FZ2Y5U1 (Methotrexate) |
| تواريخ الأحداث: | Date Created: 20020403 Date Completed: 20020410 Latest Revision: 20131121 |
| رمز التحديث: | 20231215 |
| PMID: | 11925909 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0300-9157 |
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