دورية أكاديمية
Expression of the breast cancer resistance protein in breast cancer.
| العنوان: | Expression of the breast cancer resistance protein in breast cancer. |
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| المؤلفون: | Faneyte IF; Department of Experimental Therapy, The Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands., Kristel PM, Maliepaard M, Scheffer GL, Scheper RJ, Schellens JH, van de Vijver MJ |
| المصدر: | Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2002 Apr; Vol. 8 (4), pp. 1068-74. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: The Association Country of Publication: United States NLM ID: 9502500 Publication Model: Print Cited Medium: Print ISSN: 1078-0432 (Print) Linking ISSN: 10780432 NLM ISO Abbreviation: Clin Cancer Res Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Denville, NJ : The Association, c1995- |
| مواضيع طبية MeSH: | Neoplasm Proteins*, ATP-Binding Cassette Transporters/*genetics , Breast Neoplasms/*genetics, ATP Binding Cassette Transporter, Subfamily G, Member 2 ; ATP-Binding Cassette Transporters/metabolism ; Antibiotics, Antineoplastic/therapeutic use ; Blotting, Northern ; Breast Neoplasms/drug therapy ; Breast Neoplasms/metabolism ; Drug Resistance, Multiple ; Drug Resistance, Neoplasm ; Epirubicin/therapeutic use ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Immunohistochemistry ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Survival Analysis ; Tumor Cells, Cultured |
| مستخلص: | Purpose: The breast cancer resistance protein (BCRP) is involved in in vitro multidrug resistance and was first identified in the breast cancer cell line MCF7/AdrVp. The aim of this study was to investigate the role of BCRP in resistance of breast cancer to anthracycline treatment. Experimental Design: BCRP mRNA was determined with real-time reverse transcription-PCR and immunostaining in nine breast cancer cell lines and in samples of 25 primary breast carcinomas and 27 patients who received preoperative anthracycline-based therapy. Tumor response to treatment and patient survival were recorded. Results: In cell lines, only MCF7 and BT20 had BCRP mRNA levels coinciding with membrane-bound immunostaining. In clinical samples, BCRP expression varied widely (range, 0.01-0.86). With immunohistochemistry, BCRP was detected in vessels and normal breast epithelium but not in tumor cells. There was no difference in BCRP expression between anthracycline-naïve and treated tumor samples. BCRP expression was not associated with decreased response or survival. Conclusions: There is no indication that elevated BCRP expression in breast carcinomas confers resistance to anthracyclines. Expression was not detectable with immunohistochemistry. |
| المشرفين على المادة: | 0 (ABCG2 protein, human) 0 (ATP Binding Cassette Transporter, Subfamily G, Member 2) 0 (ATP-Binding Cassette Transporters) 0 (Antibiotics, Antineoplastic) 0 (Neoplasm Proteins) 0 (RNA, Messenger) 3Z8479ZZ5X (Epirubicin) |
| تواريخ الأحداث: | Date Created: 20020412 Date Completed: 20020812 Latest Revision: 20231024 |
| رمز التحديث: | 20240627 |
| PMID: | 11948115 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1078-0432 |
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