دورية أكاديمية
Effect of intramuscular botulinum toxin injection on upper limb spasticity in stroke patients.
| العنوان: | Effect of intramuscular botulinum toxin injection on upper limb spasticity in stroke patients. |
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| المؤلفون: | Wang HC; Department of Neurology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan, Republic of China., Hsieh LF, Chi WC, Lou SM |
| المصدر: | American journal of physical medicine & rehabilitation [Am J Phys Med Rehabil] 2002 Apr; Vol. 81 (4), pp. 272-8. |
| نوع المنشور: | Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 8803677 Publication Model: Print Cited Medium: Print ISSN: 0894-9115 (Print) Linking ISSN: 08949115 NLM ISO Abbreviation: Am J Phys Med Rehabil Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Hagerstown, MD : Lippincott Williams & Wilkins Original Publication: [Baltimore, MD] : Published by Williams & Wilkins for the Association of Academic Physiatrists, [c1988- |
| مواضيع طبية MeSH: | Arm* , Stroke Rehabilitation*, Botulinum Toxins, Type A/*therapeutic use , Neuromuscular Agents/*therapeutic use , Paraparesis, Spastic/*drug therapy, Activities of Daily Living ; Adult ; Aged ; Botulinum Toxins, Type A/pharmacology ; Female ; Hand Strength ; Humans ; Injections, Intramuscular ; Male ; Middle Aged ; Neuromuscular Agents/pharmacology ; Paraparesis, Spastic/etiology ; Range of Motion, Articular/drug effects ; Statistics, Nonparametric ; Stroke/complications |
| مستخلص: | Objective: To evaluate the therapeutic effect of intramuscular injection of botulinum toxin on spasticity of the upper limb, with emphasis on its influence over limb function. Design: An open-label, noncontrolled trial with a duration of 12 wk was designed to determine the safety and efficacy of intramuscular botulinum toxin A injection in the treatment of 16 patients with stroke with spastic hemiparesis. Electromyographically guided intramuscular botulinum toxin A injections were applied to the spastic limbs. A detailed scale system was used for the evaluation of muscle tone and functional changes induced by botulinum toxin A treatment. Results: No major side effect secondary to botulinum toxin A injection was reported. Statistically significant (P < 0.05) improvements of muscle tone, joint range of motion, hand muscle strength, and muscular pain were seen after the injection. The improvements lasted up to 8-12 wk after the treatment. However, there was no significant functional improvement except in two of the patients. Conclusions: Botulinum toxin A injection may help relieve upper limb spasticity and pain in patients with stroke. Its effect on function is probably determined by case selection. |
| المشرفين على المادة: | 0 (Neuromuscular Agents) EC 3.4.24.69 (Botulinum Toxins, Type A) |
| تواريخ الأحداث: | Date Created: 20020416 Date Completed: 20020501 Latest Revision: 20190916 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1097/00002060-200204000-00005 |
| PMID: | 11953544 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0894-9115 |
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| DOI: | 10.1097/00002060-200204000-00005 |