دورية أكاديمية
Early use of recombinant factor VIIa improves mean arterial pressure and may potentially decrease mortality in experimental hemorrhagic shock: a pilot study.
| العنوان: | Early use of recombinant factor VIIa improves mean arterial pressure and may potentially decrease mortality in experimental hemorrhagic shock: a pilot study. |
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| المؤلفون: | Lynn M; Division of Trauma and Surgical Critical Care, University of Miami School of Medicine, Miami, Florida 33101, USA., Jerokhimov I, Jewelewicz D, Popkin C, Johnson EW, Rashid QN, Brown M, Martinowitz U, Cohn SM |
| المصدر: | The Journal of trauma [J Trauma] 2002 Apr; Vol. 52 (4), pp. 703-7. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0376373 Publication Model: Print Cited Medium: Print ISSN: 0022-5282 (Print) Linking ISSN: 00225282 NLM ISO Abbreviation: J Trauma Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 1998- : Baltimore, MD : Lippincott Williams & Wilkins Original Publication: Baltimore, Williams & Wilkins. |
| مواضيع طبية MeSH: | Blood Pressure/*drug effects , Factor VIIa/*therapeutic use , Shock, Hemorrhagic/*drug therapy , Shock, Hemorrhagic/*physiopathology, Animals ; Liver/injuries ; Pilot Projects ; Prothrombin Time ; Random Allocation ; Recombinant Proteins/therapeutic use ; Swine ; Time Factors |
| مستخلص: | Background: Recombinant factor VIIa (rFVIIa) is used for treatment of bleeding episodes in hemophilia patients who develop inhibitors to factors VIII and IX. We tested the hypothesis that administration of rFVIIa early after injury would decrease bleeding and improve survival after experimental hepatic trauma. Methods: Anesthetized swine were cannulated for blood sampling and hemodynamic monitoring. Avulsion of left median lobe of the liver induced uncontrolled hemorrhage. After a 10% reduction of mean arterial pressure, animals were blindly randomized to receive intravenous rFVIIa (180 microg/kg) (n = 6) or placebo (n = 7). Results: Mortality was 43% (three of seven) in controls versus 0% with rFVIIa (p = 0.08, chi2). Significantly shorter prothrombin time and higher mean arterial pressures were observed in the rFVIIa group. Conclusion: Intravenous administration of rFVIIa early after induction of hemorrhage shortens prothrombin time and improves mean arterial pressure. A trend toward improved survival was observed. |
| المشرفين على المادة: | 0 (Recombinant Proteins) EC 3.4.21.21 (Factor VIIa) |
| تواريخ الأحداث: | Date Created: 20020417 Date Completed: 20020509 Latest Revision: 20190711 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1097/00005373-200204000-00016 |
| PMID: | 11956387 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0022-5282 |
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| DOI: | 10.1097/00005373-200204000-00016 |