دورية أكاديمية
Comparative analysis of the genomes of the temperate bacteriophages phi 11, phi 12 and phi 13 of Staphylococcus aureus 8325.
| العنوان: | Comparative analysis of the genomes of the temperate bacteriophages phi 11, phi 12 and phi 13 of Staphylococcus aureus 8325. |
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| المؤلفون: | Iandolo JJ; Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, P.O. Box 26901, Oklahoma City, OK 73190, USA. john-iandolo@ouhsc.edu, Worrell V, Groicher KH, Qian Y, Tian R, Kenton S, Dorman A, Ji H, Lin S, Loh P, Qi S, Zhu H, Roe BA |
| المصدر: | Gene [Gene] 2002 May 01; Vol. 289 (1-2), pp. 109-18. |
| نوع المنشور: | Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier/North-Holland Country of Publication: Netherlands NLM ID: 7706761 Publication Model: Print Cited Medium: Print ISSN: 0378-1119 (Print) Linking ISSN: 03781119 NLM ISO Abbreviation: Gene Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam, Elsevier/North-Holland, 1976- |
| مواضيع طبية MeSH: | Genome, Viral*, Staphylococcus Phages/*genetics, Base Composition ; DNA, Circular/genetics ; DNA, Viral/genetics ; Databases, Nucleic Acid ; Open Reading Frames/genetics ; Phylogeny ; Restriction Mapping ; Species Specificity ; Staphylococcus aureus/virology |
| مستخلص: | The genomes of the three temperate bacteriophages contained in the chromosome of Staphylococcus aureus 8325 have been extracted from the sequence database and analyzed. phi 11, phi 12 and phi 13 are members of the same lytic group but different serogroups and consequently co-habitate the same host cell. Their genomes are approximately 42 kb to 45 kb and contain about 90 ORFs of at least 50 codons. Of these, about 50 have similarities to known genes or to genes of other staphylococcal phages. Each of the phages clusters within a homology group that share large regions of sequence identity while intergroup homology is comparatively low. The arrangement of genes on the chromosomes of the three phages is similar and consistent with current modular theory of phage gene organization. The replicated genomes appear to be packaged by different mechanisms. Phage phi 11 and phi 12 have been found to contain sequences consistent with pac-site phages while phi 13 has sequences consistent with cos-site phages. The attBsite for phi 11 is located in an intergenic region of the S. aureus chromosome while phi 12 and phi 13 integrate into specific genes. The phi 12 att-site is within an unknown gene, but the phi 13 att-site is within the beta-toxin gene. In contrast to the other two phages, phi 13 also introduces the staphylokinase gene (sak) and a second gene related to expression of fib. |
| معلومات مُعتمدة: | AI-43568 United States AI NIAID NIH HHS; AI07364 United States AI NIAID NIH HHS |
| المشرفين على المادة: | 0 (DNA, Circular) 0 (DNA, Viral) |
| تواريخ الأحداث: | Date Created: 20020531 Date Completed: 20020812 Latest Revision: 20220317 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/s0378-1119(02)00481-x |
| PMID: | 12036589 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0378-1119 |
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| DOI: | 10.1016/s0378-1119(02)00481-x |