دورية أكاديمية
Intravenous parecoxib sodium foracute pain after orthopedic knee surgery.
| العنوان: | Intravenous parecoxib sodium foracute pain after orthopedic knee surgery. |
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| المؤلفون: | Rasmussen GL; Total Joint Replacement, Orthopedic Specialty Hospital, Murray, Utah, USA., Steckner K, Hogue C, Torri S, Hubbard RC |
| المصدر: | American journal of orthopedics (Belle Mead, N.J.) [Am J Orthop (Belle Mead NJ)] 2002 Jun; Vol. 31 (6), pp. 336-43. |
| نوع المنشور: | Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Frontline Medical Communications Country of Publication: United States NLM ID: 9502918 Publication Model: Print Cited Medium: Print ISSN: 1078-4519 (Print) Linking ISSN: 10784519 NLM ISO Abbreviation: Am J Orthop (Belle Mead NJ) Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <1997-2018> : Parsippany, NJ : Frontline Medical Communications Original Publication: Belle Meade, N.J. : Excerpta Medica, Inc., c1994- |
| مواضيع طبية MeSH: | Arthroplasty, Replacement, Knee/*methods , Isoxazoles/*administration & dosage , Ketorolac/*administration & dosage , Knee Joint/*surgery , Morphine/*administration & dosage , Pain, Postoperative/*drug therapy, Aged ; Analgesia/methods ; Dose-Response Relationship, Drug ; Double-Blind Method ; Drug Administration Schedule ; Female ; Humans ; Injections, Intravenous ; Knee Joint/physiopathology ; Male ; Middle Aged ; Pain Measurement ; Pain, Postoperative/diagnosis ; Sensitivity and Specificity ; Treatment Outcome |
| مستخلص: | Our objective in a randomized, multicenter, double-blind, parallel-group, placebo- and active-controlled study was to evaluate and compare the analgesic effectiveness of single intravenous (IV) doses of parecoxib sodium 20 and 40 mg, morphine 4 mg, and ketorolac 30 mg in the postsurgical orthopedic pain model. After undergoing unilateral total knee replacement surgery, 208 healthy adult patients were randomized to receive placebo or a study drug within 6 hours of discontinuation of patient-controlled analgesia on postoperative day 1. Onset of analgesia was similarly rapid with IV parecoxib sodium 40 mg, morphine, and ketorolac. Level and duration of analgesia were significantly superior with parecoxib sodium than with morphine and were similar for parecoxib sodium and ketorolac. Parecoxib sodium was safe and well tolerated. In conclusion, IV parecoxib sodium 40 mg is as effective as ketorolac 30 mg and is more effective than morphine 4 mg and therefore has potential widespread utility in acute postoperative pain management. |
| المشرفين على المادة: | 0 (Isoxazoles) 76I7G6D29C (Morphine) 9TUW81Y3CE (parecoxib) YZI5105V0L (Ketorolac) |
| تواريخ الأحداث: | Date Created: 20020627 Date Completed: 20021217 Latest Revision: 20220316 |
| رمز التحديث: | 20240627 |
| PMID: | 12083587 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1078-4519 |
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