دورية أكاديمية
Spectrophotometric determination of etidocaine in pharmaceutical (dental) formulation.
العنوان: | Spectrophotometric determination of etidocaine in pharmaceutical (dental) formulation. |
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المؤلفون: | Silva N; Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul (UFRGS), Av. Ipiranga, 2752, Porto Alegre, R/S, CEP 90160-000, Porto Alegre, Brazil. nieelson@hotmail.com, Schapoval EE |
المصدر: | Journal of pharmaceutical and biomedical analysis [J Pharm Biomed Anal] 2002 Jul 20; Vol. 29 (4), pp. 749-54. |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Elsevier Science Country of Publication: England NLM ID: 8309336 Publication Model: Print Cited Medium: Print ISSN: 0731-7085 (Print) Linking ISSN: 07317085 NLM ISO Abbreviation: J Pharm Biomed Anal Subsets: MEDLINE |
أسماء مطبوعة: | Publication: <2006->: London : Elsevier Science Original Publication: Oxford ; New York : Pergamon Press, c1983- |
مواضيع طبية MeSH: | Anesthesia, Dental*, Anesthetics, Local/*analysis , Etidocaine/*analysis , Pharmaceutical Preparations/*analysis, Anesthetics, Local/chemistry ; Bromcresol Green/chemistry ; Buffers ; Etidocaine/chemistry ; Reproducibility of Results ; Sodium Acetate ; Spectrophotometry |
مستخلص: | A spectrophotometric method was developed for the determination of etidocaine hydrochloride (EH) in injectable pharmaceutical preparation. The proposal of this work was to develop a rapid, simple, inexpensive, precise and accurate visible spectrophotometric method. The method is based on the formation of the ion-pair complex by the EH reaction with bromocresol green in the pH 4.6 which after chloroform extraction gives a yellow color that in basic medium change to blue color and exhibits a maximum absorbance at 625 nm. The calibration graph was linear over the range 2.0-6.0 microg ml(-1) EH calculated on the final yellow solution. The R.S.D. of the slope of the four lines was 0.73%. This method can be applied to injectable pharmaceutical preparation dosage studied. |
المشرفين على المادة: | 0 (Anesthetics, Local) 0 (Buffers) 0 (Pharmaceutical Preparations) 4550K0SC9B (Sodium Acetate) 8YGN0Y942M (Bromcresol Green) I6CQM0F31V (Etidocaine) |
تواريخ الأحداث: | Date Created: 20020703 Date Completed: 20021021 Latest Revision: 20190815 |
رمز التحديث: | 20240627 |
DOI: | 10.1016/s0731-7085(02)00180-2 |
PMID: | 12093505 |
قاعدة البيانات: | MEDLINE |
تدمد: | 0731-7085 |
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DOI: | 10.1016/s0731-7085(02)00180-2 |