دورية أكاديمية
Microbiological assay for azithromycin in pharmaceutical formulations.
| العنوان: | Microbiological assay for azithromycin in pharmaceutical formulations. |
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| المؤلفون: | Breier AR; Departamento de Produção e Controle de Qualidade de Medicamentos, Universidade Federal do Rio Grande do Sul, Faculdade de Farmácia, Av. Ipiranga, 2752, -RS 90610-000, Porto Alegre, Brazil. anarita_breier@hotmail.com, Garcia CV, Oppe TP, Steppe M, Schapoval EE |
| المصدر: | Journal of pharmaceutical and biomedical analysis [J Pharm Biomed Anal] 2002 Jul 31; Vol. 29 (5), pp. 957-61. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Validation Study |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Country of Publication: England NLM ID: 8309336 Publication Model: Print Cited Medium: Print ISSN: 0731-7085 (Print) Linking ISSN: 07317085 NLM ISO Abbreviation: J Pharm Biomed Anal Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2006->: London : Elsevier Science Original Publication: Oxford ; New York : Pergamon Press, c1983- |
| مواضيع طبية MeSH: | Anti-Bacterial Agents/*pharmacology , Azithromycin/*pharmacology , Micrococcus luteus/*drug effects, Microbial Sensitivity Tests ; Reproducibility of Results |
| مستخلص: | The validation of a microbiological assay, applying the cylinder-plate method, for the determination of the antibiotic azithromycin is described. Using a strain of Micrococcus luteus ATCC 9341 as the test organism, azithromycin at concentrations ranging from 0.1 to 0.4 microgml(-1) could be measured in capsules and suspensions. A prospective validation of the method showed that it was linear (r=0.998), precise (RSD=1.40-capsules; RSD=1.19-powder for suspension and RSD=1.73-oral suspension) and accurate (it measured the added quantities). We conclude that the microbiological assay is satisfactory for quantitation of in vitro antibacterial activity of azithromycin. |
| المشرفين على المادة: | 0 (Anti-Bacterial Agents) 83905-01-5 (Azithromycin) |
| تواريخ الأحداث: | Date Created: 20020703 Date Completed: 20020905 Latest Revision: 20191210 |
| رمز التحديث: | 20240627 |
| DOI: | 10.1016/s0731-7085(02)00213-3 |
| PMID: | 12093530 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0731-7085 |
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| DOI: | 10.1016/s0731-7085(02)00213-3 |