دورية أكاديمية
5,5-Fused thiophene gamma-lactams as templates for serine protease inhibition.
| العنوان: | 5,5-Fused thiophene gamma-lactams as templates for serine protease inhibition. |
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| المؤلفون: | Migaud ME; Oxford Centre for Molecular Sciences, Dyson Perrins Laboratory, South Parks Road, Oxford, UK OX1 3QY., Wilmouth RC, Mills GI, Wayne GJ, Risley C, Chambers C, Macdonald SJ, Schofield CJ |
| المصدر: | Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2002 Jun 21 (12), pp. 1274-5. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 9610838 Publication Model: Print Cited Medium: Print ISSN: 1359-7345 (Print) Linking ISSN: 13597345 NLM ISO Abbreviation: Chem Commun (Camb) Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Cambridge : Royal Society of Chemistry |
| مواضيع طبية MeSH: | Lactams/*chemical synthesis , Serine Proteinase Inhibitors/*chemical synthesis , Thiophenes/*chemical synthesis, Alkylating Agents/chemical synthesis ; Animals ; Binding Sites ; Crystallography, X-Ray ; Humans ; Leukocyte Elastase/antagonists & inhibitors ; Mass Spectrometry ; Molecular Conformation ; Pancreatic Elastase/antagonists & inhibitors ; Swine |
| مستخلص: | Novel 5,5-fused thiophene lactams are potent inhibitors and acylating agents of HNE and PPE. |
| المشرفين على المادة: | 0 (Alkylating Agents) 0 (Lactams) 0 (Serine Proteinase Inhibitors) 0 (Thiophenes) EC 3.4.21.36 (Pancreatic Elastase) EC 3.4.21.37 (Leukocyte Elastase) |
| تواريخ الأحداث: | Date Created: 20020712 Date Completed: 20020802 Latest Revision: 20190901 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1039/b111627d |
| PMID: | 12109112 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1359-7345 |
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| DOI: | 10.1039/b111627d |