دورية أكاديمية
Ocular drug delivery using 20-kHz ultrasound.
| العنوان: | Ocular drug delivery using 20-kHz ultrasound. |
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| المؤلفون: | Zderic V; Department of Bioengineering, University of Washington, Seattle, WA, USA. vesna@u.washington.edu, Vaezy S, Martin RW, Clark JI |
| المصدر: | Ultrasound in medicine & biology [Ultrasound Med Biol] 2002 Jun; Vol. 28 (6), pp. 823-9. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Pergamon Press Country of Publication: England NLM ID: 0410553 Publication Model: Print Cited Medium: Print ISSN: 0301-5629 (Print) Linking ISSN: 03015629 NLM ISO Abbreviation: Ultrasound Med Biol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Oxford, New York, Pergamon Press. |
| مواضيع طبية MeSH: | Ultrasonics*, Adrenergic beta-Antagonists/*administration & dosage , Cornea/*metabolism , Drug Delivery Systems/*methods , Timolol/*administration & dosage, Adrenergic beta-Antagonists/pharmacokinetics ; Animals ; Atenolol/administration & dosage ; Atenolol/pharmacokinetics ; Betaxolol/administration & dosage ; Betaxolol/pharmacokinetics ; Carteolol/administration & dosage ; Carteolol/pharmacokinetics ; Epithelium/drug effects ; Epithelium/metabolism ; Models, Animal ; Permeability ; Rabbits ; Timolol/pharmacokinetics |
| مستخلص: | The cornea is a major pathway for drug delivery to diseased eye structures. We have investigated the application of 1-s bursts of 20-kHz ultrasound, at I(SAPA) of 14 W/cm(2) (I(SATA) of 2 W/cm(2)), for enhancement of corneal permeability to glaucoma drugs of different lipophilicity (atenolol, carteolol, timolol and betaxolol). The permeability of rabbit cornea increased by 2.6 times for atenolol, 2.8 for carteolol, 1.9 for timolol and 4.4 times for betaxolol (all p-values < 0.05), after 60 min of ultrasound (US) exposure in vitro. The differences between the treatment and control experiments were statistically significant after 10 to 30 min of US exposure for all four drugs. US application appeared to produce epithelial disorganization and structural changes in the corneal stroma. Further studies are needed to determine the optimal US parameters for a safe and effective treatment. |
| معلومات مُعتمدة: | R01 EY004542 United States EY NEI NIH HHS |
| المشرفين على المادة: | 0 (Adrenergic beta-Antagonists) 50VV3VW0TI (Atenolol) 817W3C6175 (Timolol) 8NF31401XG (Carteolol) O0ZR1R6RZ2 (Betaxolol) |
| تواريخ الأحداث: | Date Created: 20020713 Date Completed: 20021106 Latest Revision: 20190901 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/s0301-5629(02)00515-x |
| PMID: | 12113795 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0301-5629 |
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| DOI: | 10.1016/s0301-5629(02)00515-x |