دورية أكاديمية
Presence of distinct virtual backbone torsion angles in dipeptide conformers.
| العنوان: | Presence of distinct virtual backbone torsion angles in dipeptide conformers. |
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| المؤلفون: | Gupta S; School of Biological Sciences, University of Wales Bangor, Gwynedd LL57 2UW, UK., Grail BM, Payne JW |
| المصدر: | Protein and peptide letters [Protein Pept Lett] 2002 Apr; Vol. 9 (2), pp. 133-8. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Bentham Science Publishers Country of Publication: Netherlands NLM ID: 9441434 Publication Model: Print Cited Medium: Print ISSN: 0929-8665 (Print) Linking ISSN: 09298665 NLM ISO Abbreviation: Protein Pept Lett Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Hilversum, The Netherlands : Bentham Science Publishers Original Publication: Schiphol, The Netherlands : Bentham Science Publishers, c1994- |
| مواضيع طبية MeSH: | Peptides/*chemistry, Calorimetry ; Ions ; Ligands ; Models, Molecular ; Protein Conformation ; Protein Transport |
| مستخلص: | Zwitterionic dipeptides have recently been shown to exist in water mainly as nine conformational forms with specific combinations of backbone Psi, omega and Phi torsions, which allows conformer-specific molecular recognition of peptide ligands by proteins. Here, we show that pairs of virtual backbone torsions can also define these nine conformational forms, and that comparing these virtual torsions in dipeptides with those of backbone-modified pseudopeptides offers an improved procedure for evaluating peptidomimetics for therapeutic applications. |
| المشرفين على المادة: | 0 (Ions) 0 (Ligands) 0 (Peptides) |
| تواريخ الأحداث: | Date Created: 20020727 Date Completed: 20021219 Latest Revision: 20190910 |
| رمز التحديث: | 20221213 |
| DOI: | 10.2174/0929866023408904 |
| PMID: | 12141910 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0929-8665 |
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| DOI: | 10.2174/0929866023408904 |